All Outputs (47)

Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis (2024)
Journal Article

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN), following drug administration. The study protocol was registered on PROSPERO. The Preferred Reportin... Read More about Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis.

Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma (2024)
Journal Article

Background Autofluorescence (AF)–Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The technology does not require tissue fixation, st... Read More about Diagnostic accuracy of autofluorescence-Raman microspectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article

Objectives Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review (2024)
Journal Article

Objectives Observational studies are not subject to the same requirements as randomized controlled trials, such as registration or publishing a protocol. The aim of this scoping review was to estimate the registration rate of observational studies i... Read More about The majority of observational studies in leading peer-reviewed medicine journals are not registered and do not have a publicly accessible protocol: a scoping review.

International melanoma and non melanoma skin cancer mortality trends: is it time to refocus our attention? (2023)
Journal Article

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Working Paper

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

“Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England (2023)
Journal Article

Background Providing detailed skin cancer statistics, including incidence and survival, by tumour type and patient characteristics is important for up-to-date epidemiological information. Objectives To create a new clinically relevant consensus-... Read More about “Get Data Out” Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

MULTIPLE ways to correct for MULTIPLE comparisons in MULTIPLE types of studies (2021)
Journal Article

Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study) (2021)
Journal Article

Background In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults. Objectives To test the diagnostic accuracy of previously agreed consensus criteria and develop... Read More about Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study).

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis (2021)
Journal Article

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that ha... Read More about Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

The global incidence of bullous pemphigoid: a systematic review and meta-analysis (2021)
Journal Article

Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study... Read More about The global incidence of bullous pemphigoid: a systematic review and meta-analysis.

Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study (2021)
Journal Article

Increasing evidence suggests the pathogenesis of male genital lichen sclerosus (LS) is driven by chronic, occluded exposure of susceptible epithelium to the irritant effect of urine (1, 2). It is not clear how this can be extrapolated to females, how... Read More about Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis (2021)
Journal Article

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis.

Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records (2021)
Journal Article

Objective To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA). Methods A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with... Read More about Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records.

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis (2021)
Journal Article

Background Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epith... Read More about Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis.

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England (2021)
Journal Article

Background Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size of the pool of potential part... Read More about Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.