Risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, following drug administration: a systematic review and meta-analysis

Fathima, Samaah; Grainge, Matthew J; Wainman, Hannah; Swiderski, Mikolaj; Gran, Sonia

Abstract

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN), following drug administration. The study protocol was registered on PROSPERO. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. On 17th October 2022, a search, advised by a librarian, was conducted in Medline and EMBASE. Five studies were pooled. We report that HIV and male gender may be risk factors for SJS/TEN however this review was limited by a low number, and quality, of included studies. We conclude a well-designed, large population-based case-control study with an appropriate control group is required to assess risk factors for development of drug-induced SJS/TEN.

• Journal Article Type: Article
• Acceptance Date: May 13, 2024
• Online Publication Date: May 15, 2024
• Publication Date: May 15, 2024
• Deposit Date: May 22, 2024
• Publicly Available Date: May 16, 2025
• Journal: Clinical and Experimental Dermatology
• Print ISSN: 0307-6938
• Electronic ISSN: 1365-2230
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1093/ced/llae183
• Public URL: https://nottingham-repository.worktribe.com/output/35151850
• Publisher URL: https://academic.oup.com/ced/advance-article-abstract/doi/10.1093/ced/llae183/7673543?redirectedFrom=fulltext&login=false