All Outputs (26)

Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis (2023)
Journal Article
Yule, A., Sills, D., Smith, S., Spiller, R., & Smyth, A. R. (2023). Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis. Expert Review of Respiratory Medicine, 17(7), 547-561. https://doi.org/10.1080/17476348.2023.2228194

Introduction Gastrointestinal (GI)-related symptoms, complications, and comorbidities in cystic fibrosis (CF) are common and research to reduce their burden is a priority for the CF community. To enable future research, this review aimed to summariz... Read More about Thinking outside the box: a review of gastrointestinal symptoms and complications in cystic fibrosis.

A refresh of the top 10 research priorities in cystic fibrosis (2023)
Journal Article
Rowbotham, N. J., Smith, S., Elliott, Z. C., Cupid, B., Allen, L. J., Cowan, K., …Smyth, A. R. (2023). A refresh of the top 10 research priorities in cystic fibrosis. Thorax, 78(8), 840-843. https://doi.org/10.1136/thorax-2023-220100

In 2018 we published the James Lind Alliance (JLA) top 10 priorities for clinical research in cystic fibrosis (CF), chosen jointly by the patient and clinical communities. These priorities have led to new research funding. To establish whether priori... Read More about A refresh of the top 10 research priorities in cystic fibrosis.

Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis (2023)
Journal Article
Smith, S., Calthorpe, R., Herbert, S., & Smyth, A. R. (2023). Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis. Cochrane Database of Systematic Reviews, 2023(2), Article CD013733. https://doi.org/10.1002/14651858.cd013733.pub2

Background: Improved understanding and treatment of cystic fibrosis (CF) has led to longer life expectancy, which is accompanied by an increasingly complex regimen of treatments.Suboptimal adherence to the treatment plan, in the context of respirator... Read More about Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis.

Working in partnership with the patient community to develop outline trial designs in CF (2021)
Journal Article
Rowbotham, N. J., Smith, S., Davies, G., Leighton, P., Rayner, O., Elliott, Z., …Smyth, A. R. (2022). Working in partnership with the patient community to develop outline trial designs in CF. Journal of Cystic Fibrosis, 21(2), 300-301. https://doi.org/10.1016/j.jcf.2021.12.008

In a collaboration between health professionals and the patient community, we previously identified the Top 10 priorities for clinical research in CF [ [1] ]. Here, we have used a similar approach to explore four of these priorities further and sugge... Read More about Working in partnership with the patient community to develop outline trial designs in CF.

Exploring the challenges of accessing medication for patients with cystic fibrosis (2021)
Journal Article
Herbert, S., Rowbotham, N., Smith, S., Wilson, P., Elliott, Z., Leighton, P., …Smyth, A. R. (2022). Exploring the challenges of accessing medication for patients with cystic fibrosis. Thorax, 77(3), 295-297. https://doi.org/10.1136/thoraxjnl-2021-217140

Reducing treatment burden in cystic fibrosis (CF) is the top research priority for patients and clinicians. Difficulty accessing medication is one aspect of treatment burden. We investigated this with an online survey available globally for patients... Read More about Exploring the challenges of accessing medication for patients with cystic fibrosis.

Outcomes and endpoints reported in studies of pulmonary exacerbations in people with cystic fibrosis: A systematic review (2020)
Journal Article
McLeod, C., Wood, J., Schultz, A., Norman, R., Smith, S., Blyth, C. C., …Snelling, T. L. (2020). Outcomes and endpoints reported in studies of pulmonary exacerbations in people with cystic fibrosis: A systematic review. Journal of Cystic Fibrosis, 19(6), 858-867. https://doi.org/10.1016/j.jcf.2020.08.015

Background: There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations in people with cystic fibrosis (CF). Outcomes used for evaluation should be meaningful; that is, they should capture how people feel, fun... Read More about Outcomes and endpoints reported in studies of pulmonary exacerbations in people with cystic fibrosis: A systematic review.

How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey (2020)
Journal Article
Smith, S., Rowbotham, N., Davies, G., Gathercole, K., Collins, S. J., Elliott, Z., …Smyth, A. (2020). How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey. BMJ Open Respiratory Research, 7(1), Article e000614. https://doi.org/10.1136/bmjresp-2020-000614

Introduction Relieving gastrointestinal (GI) symptoms was identified as a ‘top ten’ priority by our James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF). We conducted an online survey to find out more about the effect of GI sympto... Read More about How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey.

What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment? (2020)
Journal Article
Calthorpe, R. J., Smith, S. J., Rowbotham, N. J., Leighton, P. A., Davies, G., Daniels, T., …Smyth, A. R. (2020). What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?. BMJ Open Respiratory Research, 7(1), Article e000601. https://doi.org/10.1136/bmjresp-2020-000601

Introduction: “What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?” was identified as one of the James Lind Alliance Priority Setting Partnership’s top 10 research q... Read More about What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?.

Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials (2019)
Journal Article
Davies, G., Rowbotham, N. J., Smith, S., Elliot, Z. C., Gathercole, K., Rayner, O., …Smyth, A. R. (2020). Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials. Journal of Cystic Fibrosis, 19(3), 499-502. https://doi.org/10.1016/j.jcf.2019.10.025

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: “What are effective ways of simplifying the treatment burden of people with CF?” We aimed to summarise the lived exp... Read More about Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials.

Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review (2019)
Journal Article
Calthorpe, R. J., Smith, S., Gathercole, K., & Smyth, A. R. (2020). Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review. Thorax, 75(1), 72-77. https://doi.org/10.1136/thoraxjnl-2019-213233

Digital healthcare is a rapidly growing healthcare sector. Its importance has been recognised at both national and international level, with the WHO recently publishing its first global strategy for digital health. The use of digital technology withi... Read More about Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: A state of the art review.

Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against (2019)
Journal Article
Smyth, A., Smith, S., & Robotham, N. (2020). Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against. Paediatric Respiratory Reviews, 36, 94-96. https://doi.org/10.1016/j.prrv.2019.08.001

As awareness of the risks of cross infection has increased, infection prevention and control measures have become more draconian. Infection control measures can have a profound effect of the organisation and delivery of CF services and on the lives o... Read More about Pro Con debates in clinical medicine Infection prevention and control in cystic fibrosis: one size fits all? The argument against.

Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review (2019)
Journal Article
Kalaitzis, I., Rowbotham, N., Smith, S., & Smyth, A. (2019). Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.06.005

There are many uncertainties regarding Cystic Fibrosis (CF) treatment. Recently, the first James Lind Alliance (JLA) Priority Setting Partnership (PSP) in CF was completed, bringing clinicians, patients and carers together to identify the Top 10 rese... Read More about Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review.

Is microfinance associated with changes in women's wellbeing and children's nutrition? a systematic review and meta-analysis (2019)
Journal Article
Gichuru, W., Ojha, S., Smith, S., Smyth, A. R., & Szatkowski, L. (2019). Is microfinance associated with changes in women's wellbeing and children's nutrition? a systematic review and meta-analysis. BMJ Open, 9(1), Article e023658. https://doi.org/10.1136/bmjopen-2018-023658

Background: Microfinance is the provision of savings and small loans services, with no physical collateral. Most recipients are disadvantaged women. The social and health impacts of microfinance have not been comprehensively evaluated. Objective: To... Read More about Is microfinance associated with changes in women's wellbeing and children's nutrition? a systematic review and meta-analysis.

Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review (2018)
Journal Article
Rowbotham, N., Smith, S., Robinson, K., & Smyth, A. (2019). Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review. Thorax, 74(3), 229-236. https://doi.org/10.1136/thoraxjnl-2017-210858

Introduction:Cystic fibrosis (CF) is a multisystem disorder. Treatment is complex and evidence for treatment decisions may be absent. Characterising gaps in the research evidence will highlight treatment uncertainties and help prioritise research que... Read More about Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review.

Working with the patient and clinical community to deliver clinical research in cystic fibrosis: James Lind CF Phase II (2018)
Other
Smith, S., Rowbotham, N. J., & Smyth, A. R. (2018). Working with the patient and clinical community to deliver clinical research in cystic fibrosis: James Lind CF Phase II. London

This is a protocol which sets out the aims, objectives and commitments of the second phase of the James Lind Alliance Priority Setting Partnership in Cystic Fibrosis and the basic roles and responsibilities of the partners therein. The James Lind... Read More about Working with the patient and clinical community to deliver clinical research in cystic fibrosis: James Lind CF Phase II.

The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and health care providers (2017)
Journal Article
Rowbotham, N. J., Smith, S., Leighton, P., Rayner, O. C., Gathercole, K., Elliott, Z., …Smyth, A. R. (2018). The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and health care providers. Thorax, 73(4), 388-390. https://doi.org/10.1136/thoraxjnl-2017-210473

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Researc... Read More about The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and health care providers.

Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review (2017)
Journal Article
Prayle, A., Cox, T., Smith, S., Rycroft-Malone, J., Thomas, K. S., Hughes, D. A., & Smyth, A. R. (in press). Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review. Thorax, https://doi.org/10.1136/thoraxjnl-2016-208790

Cochrane Reviews summarise best evidence and should inform guidelines. We assessed the use of Cochrane Reviews in the UK guidelines for paediatric respiratory disease. We found 21 guidelines which made 1025 recommendations, of which 96 could be infor... Read More about Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review.

Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis (2017)
Journal Article
Lansbury, L. E., Smith, S., Beyer, W., Karamehic, E., Pasic-Juhas, E., Sikira, H., …Nguyen-Van-Tam, J. (in press). Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis. Vaccine, https://doi.org/10.1016/j.vaccine.2017.02.059

Background: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine effectiveness (VE) for adjuvanted and unadjuvanted vacc... Read More about Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: a systematic review and meta-analysis.

Cycling infrastructure for reducing cycling injuries in cyclists (2015)
Journal Article
Mulvaney, C. A., Smith, S., Watson, M. C., Parkin, J., Coupland, C., Miller, P., …McClintock, H. (2015). Cycling infrastructure for reducing cycling injuries in cyclists. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD010415.pub2

Background: Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual’s daily routine, such as for cycling to work and to the shops, than other physical... Read More about Cycling infrastructure for reducing cycling injuries in cyclists.

General practice characteristics associated with rates of testing and detection of hepatitis C: Cross-sectional study in Nottingham and Derbyshire (2006)
Journal Article
Coupland, C., Hippisley-Cox, J., Smith, S., Irving, W., Pringle, M., Ryder, S., …Bullock, D. (2006). General practice characteristics associated with rates of testing and detection of hepatitis C: Cross-sectional study in Nottingham and Derbyshire. British Journal of General Practice, 56(529), 620-623

The aim of this study was to determine general practice characteristics associated with testing rates for hepatitis C virus (HCV) and the proportion of tests with a positive result. The study included all patients tested for HCV from all general prac... Read More about General practice characteristics associated with rates of testing and detection of hepatitis C: Cross-sectional study in Nottingham and Derbyshire.