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Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review

Kalaitzis, I.S.; Rowbotham, N.J.; Smith, S.J.; Smyth, A.R.

Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review Thumbnail


Authors

I.S. Kalaitzis

N.J. Rowbotham

SHERIE SMITH sherie.smith@nottingham.ac.uk
Cochrane Systematic Reviewer

A.R. Smyth



Abstract

There are many uncertainties regarding Cystic Fibrosis (CF) treatment. Recently, the first James Lind Alliance (JLA) Priority Setting Partnership (PSP) in CF was completed, bringing clinicians, patients and carers together to identify the Top 10 research priorities. Here we investigate how well the current clinical trials landscape reflects these priorities. Trials in CF were identified through searches of research databases (Pubmed, ANZCTR, EU clinical trials register, ClinicalTrials.gov and ISRCTN). Trials meeting inclusion criteria of registered intervention studies in CF published between 01.012016 and 11.09.2017 were matched to the Top 10 priorities. We identified 259 trials, with 193 fulfilling the inclusion criteria. Only 63 (33%) of these matched one or more of the JLA priorities showing that current clinical trials poorly reflect the JLA Top 10. By increasing awareness of the Top 10 priorities, it is hoped that this will fuel future research in areas important to the CF community.

Citation

Kalaitzis, I., Rowbotham, N., Smith, S., & Smyth, A. (2019). Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.06.005

Journal Article Type Article
Acceptance Date Jun 10, 2019
Online Publication Date Jun 22, 2019
Publication Date Jun 22, 2019
Deposit Date Jul 1, 2019
Publicly Available Date Jun 23, 2020
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Electronic ISSN 1873-5010
Publisher Elsevier
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1016/j.jcf.2019.06.005
Keywords Clinical trial; Research priority; Cystic fibrosis
Public URL https://nottingham-repository.worktribe.com/output/2246768
Publisher URL https://www.sciencedirect.com/science/article/pii/S1569199319308069?via%3Dihub
Contract Date Jul 1, 2019

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