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Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review

Rowbotham, Nicola; Smith, Sherie; Robinson, Karen; Smyth, Alan

Authors

Nicola Rowbotham

SHERIE SMITH sherie.smith@nottingham.ac.uk
Cochrane Systematic Reviewer

Karen Robinson

Alan Smyth



Abstract

Introduction:Cystic fibrosis (CF) is a multisystem disorder. Treatment is complex and evidence for treatment decisions may be absent. Characterising gaps in the research evidence will highlight treatment uncertainties and help prioritise research questions. We systematically identified the evidence gaps for treatment decisions in CF.
Methods: We searched for systematic reviews and guidelines on treatment interventions in CF. Two researchers identified eligible reviews with arbitration from a third. Using a structured framework, we extracted and characterised evidence gaps.
Results: There were 73 reviews and 21 guidelines that met our inclusion criteria. From these, we identified 148 evidence gaps across a range of treatment areas. We found 111 evidence gaps through systematic reviews and a further 37 from guidelines. The reason for an evidence gap could only be reliably characterised for systematic reviews. In most cases, there was more than one explanation—most commonly few or no trials (97/111 evidence gaps). Other important factors leading to evidence gaps were small sample size (49/111), inadequate duration of follow-up (38/111) or intervention (37/111) and factors relating to outcomes (35/111). Evidence gaps from both systematic reviews and guidelines fell into the following categories: Respiratory (91); Gastrointestinal (20); PhysiotherapyandExercise (16); Musculoskeletal (6); Endocrine (4); Basic defect of CF (8); Psychosocial (2); Ears, Nose and Throat (1).
Conclusions: We have compiled an up-to-date list of treatment uncertainties in CF and the reasons for these uncertainties. These can be used as a resource to aid researchers and funders when planning future trials.
PROSPERO registration number: Pre-results; CRD42015030111.

Citation

Rowbotham, N., Smith, S., Robinson, K., & Smyth, A. (2019). Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review. Thorax, 74(3), 229-236. https://doi.org/10.1136/thoraxjnl-2017-210858

Journal Article Type Article
Acceptance Date Aug 28, 2018
Online Publication Date Oct 9, 2018
Publication Date 2019-03
Deposit Date Sep 7, 2018
Publicly Available Date Mar 28, 2024
Journal Thorax
Print ISSN 0040-6376
Electronic ISSN 1468-3296
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 74
Issue 3
Pages 229-236
DOI https://doi.org/10.1136/thoraxjnl-2017-210858
Public URL https://nottingham-repository.worktribe.com/output/1064268
Publisher URL https://thorax.bmj.com/content/early/2018/10/09/thoraxjnl-2017-210858

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