All Outputs (4)

CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection (2023)
Journal Article
Burgess, H. M., Grande, R., Riccio, S., Dinesh, I., Winkler, G. S., Depledge, D. P., & Mohr, I. (2023). CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection. EMBO Reports, 24(12), Article e56327. https://doi.org/10.15252/embr.202256327

Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme. By performing a targeted loss-of... Read More about CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection.

Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation (2023)
Journal Article
Zhao, Q., Pavanello, L., Bartlam, M., & Winkler, G. S. (2023). Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation. Frontiers in Genetics, 14, Article 1233842. https://doi.org/10.3389/fgene.2023.1233842

In eukaryotic cells, the synthesis, processing, and degradation of mRNA are important processes required for the accurate execution of gene expression programmes. Fully processed cytoplasmic mRNA is characterised by the presence of a 5′cap structure... Read More about Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation.

Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability (2023)
Journal Article
Hagkarim, N. C., Hajkarim, M. C., Suzuki, T., Fujiwara, T., Winkler, G. S., Stewart, G. S., & Grand, R. J. (2023). Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability. Cells, 12(14), Article 1868. https://doi.org/10.3390/cells12141868

The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. It is involved i... Read More about Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability.

Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex (2023)
Journal Article
Pavanello, L., Hall, M., & Winkler, G. S. (2023). Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex. Frontiers in Cell and Developmental Biology, 11, Article 1153624. https://doi.org/10.3389/fcell.2023.1153624

Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation. In recent years, significant progress has been made about the role of sequence elements in... Read More about Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex.