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Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex

Pavanello, Lorenzo; Hall, Michael; Winkler, Gerlof Sebastiaan

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Authors

Lorenzo Pavanello

Michael Hall



Abstract

Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation. In recent years, significant progress has been made about the role of sequence elements in the 3′ untranslated region for the regulation of mRNA degradation, and a model has emerged in which recruitment of the Ccr4-Not complex is the critical step in the regulation of mRNA decay. Recruitment of the Ccr4-Not complex to a target mRNA results in deadenylation mediated by the Caf1 and Ccr4 catalytic subunits of the complex. Following deadenylation, the 5′ cap structure is removed, and the mRNA subjected to 5′-3′ degradation. Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is reviewed, with a particular focus on mechanisms of its recruitment to mRNA by sequence motifs in the 3′ untranslated region, codon usage, as well as general mechanisms involving the poly(A) tail.

Citation

Pavanello, L., Hall, M., & Winkler, G. S. (2023). Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex. Frontiers in Cell and Developmental Biology, 11, Article 1153624. https://doi.org/10.3389/fcell.2023.1153624

Journal Article Type Article
Acceptance Date Mar 20, 2023
Online Publication Date Apr 20, 2023
Publication Date Apr 20, 2023
Deposit Date Mar 21, 2023
Publicly Available Date Apr 20, 2023
Journal Frontiers in Cell and Developmental Biology
Electronic ISSN 2296-634X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 11
Article Number 1153624
DOI https://doi.org/10.3389/fcell.2023.1153624
Keywords mRNA; deadenylation; degradation; Ccr4-Not; deadenylase; gene 14 regulation; gene expression 15 16
Public URL https://nottingham-repository.worktribe.com/output/18807469
Publisher URL https://www.frontiersin.org/articles/10.3389/fcell.2023.1153624/full

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