All Outputs (17)

A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses (2023)
Journal Article

Fractures caused by bone overloading are a leading cause of euthanasia in Thoroughbred racehorses. The risk of fatal fracture has been shown to be influenced by both environmental and genetic factors but, to date, no specific genetic mechanisms under... Read More about A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses.

Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis (2022)
Journal Article

Canine atopic dermatitis is an inflammatory skin disease with clinical similarities to human atopic dermatitis. Several dog breeds are at increased risk for developing this disease but previous genetic associations are poorly defined. To identify add... Read More about Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis.

Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes (2022)
Journal Article

Racehorses competing in short (i.e., ‘sprinters’), middle- or longer-distance (i.e., ‘stayers’) flat races are assumed to have natural variation in locomotion; sprinters having an innately shorter stride than stayers. No study has objectively tested... Read More about Locomotory Profiles in Thoroughbreds: Peak Stride Length and Frequency in Training and Association with Race Outcomes.

GIFT: New method for the genetic analysis of small gene effects involving small sample sizes (2022)
Journal Article

Small gene effects involved in complex/omnigenic traits remain costly to analyse using current genome-wide association methods (GWAS) because of the number of individuals required to return meaningful association(s), a.k.a. study power. Inspired by f... Read More about GIFT: New method for the genetic analysis of small gene effects involving small sample sizes.

A Mechanogenetic Model of Exercise-Induced Pulmonary Haemorrhage in the Thoroughbred Horse (2019)
Journal Article

Exercise-induced pulmonary haemorrhage (EIPH) occurs in horses performing high-intensity athletic activity. The application of physics principles to derive a ‘physical model’, which is coherent with existing physiology and cell biology data, shows th... Read More about A Mechanogenetic Model of Exercise-Induced Pulmonary Haemorrhage in the Thoroughbred Horse.

Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus (2019)
Journal Article

Canine atopic dermatitis (cAD) is a common allergic skin condition in dogs that causes chronic pruritus. The overall quality of life in dogs with cAD is known to be reduced, and human patients with pruritic conditions report significant psychological... Read More about Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus.

Environmental risk factors for canine atopic dermatitis: a retrospective large‐scale study in Labrador and golden retrievers (2019)
Journal Article

Background - canine atopic dermatitis (cAD) is one the most common and distressing skin disorders seen in dogs. It is characterised by dysfunction in the skin barrier, with a complex pathogenesis combining both genetic and environmental factors. O... Read More about Environmental risk factors for canine atopic dermatitis: a retrospective large‐scale study in Labrador and golden retrievers.

Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies (2019)
Journal Article

Canine atopic dermatitis (cAD) is a common hereditary clinical syndrome in domestic dogs with no definitive diagnostic tests, which causes marked morbidity and has a high economic impact internationally. We created a novel questionnaire for Labrador... Read More about Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies.

Copy number variations in Friesian horses and genetic risk factors for insect bite hypersensitivity (2018)
Journal Article

Background: Many common and relevant diseases affecting equine welfare have yet to be tested regarding structural variants such as copy number variations (CNVs). CNVs make up a substantial proportion of total genetic variability in populations of man... Read More about Copy number variations in Friesian horses and genetic risk factors for insect bite hypersensitivity.

Joint genomic prediction of canine hip dysplasia in UK and US Labrador Retrievers (2018)
Journal Article

Canine hip dysplasia, a debilitating orthopedic disorder that leads to osteoarthritis and cartilage degeneration, is common in several large-sized dog breeds and shows moderate heritability suggesting that selection can reduce prevalence. Estimating... Read More about Joint genomic prediction of canine hip dysplasia in UK and US Labrador Retrievers.

Taking a broader view of things: towards a transdisciplinary approach to cancer (2017)
Journal Article

Cancer is widely considered an abnormality that emerges from within the body and which must be destroyed and defeated. But we still do not know precisely how and why cancer starts, and while a ‘magic bullet’ cure has failed to materialise, those adop... Read More about Taking a broader view of things: towards a transdisciplinary approach to cancer.

Genomic data illuminates demography, genetic structure and selection of a popular dog breed (2017)
Journal Article

BACKGROUND: Genomic methods have proved to be important tools in the analysis of genetic diversity across the range of species and can be used to reveal processes underlying both short- and long-term evolutionary change. This study applied genomic me... Read More about Genomic data illuminates demography, genetic structure and selection of a popular dog breed.

Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH) (2016)
Journal Article

While susceptibility to hypersensitive reactions is a common problem amongst humans and animals alike, the population structure of certain animal species and breeds provides a more advantageous route to better understanding the biology underpinning t... Read More about Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH).

Genomic prediction of traits related to canine hip dysplasia (2015)
Journal Article

Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retriever (2014)
Journal Article

Background Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-ass... Read More about Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retriever.

A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses (2014)
Journal Article

The utility of low-density genotyping for imputation in the Thoroughbred horse (2014)
Journal Article

Background Despite the dramatic reduction in the cost of high-density genotyping that has occurred over the last decade, it remains one of the limiting factors for obtaining the large datasets required for genomic studies of disease in the horse. In... Read More about The utility of low-density genotyping for imputation in the Thoroughbred horse.