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The role of oxidative stress in antipsychotics induced ovarian toxicity (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Khan, R., & Amer, S. A. (2017). The role of oxidative stress in antipsychotics induced ovarian toxicity. Toxicology in Vitro, 44, doi:10.1016/j.tiv.2017.07.008. ISSN 0887-2333

This study tested the hypothesis that oxidative stress could be an underlying mechanism for APs-induced ovarian cytotoxicity and reproductive dysfunction. Rat ovarian theca interstitial cells (TICs) were isolated and treated with four APs [chlorproma... Read More

Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome (2017)
Journal Article
Amer, S. A., Smith, J., Mahran, A., Fox, P., & Fakis, A. (2017). Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome. Human Reproduction, 32(8), doi:10.1093/humrep/dex227. ISSN 0268-1161

STUDY QUESTION: Would letrozole as a primary ovulation induction agent generate better pregnancy rates than clomiphene citrate (CC) in subfertile women with anovulatory polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER: Participants receiving letro... Read More

Ovarian reserve after salpingectomy: a systematic review and meta-analysis (2017)
Journal Article
Mohamed, A. A., Yosef, A. H., James, C., Al-Hussaini, T. K., Bedaiwy, M. A., & Amer, S. A. (2017). Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 96(7), doi:10.1111/aogs.13133. ISSN 0001-6349

Introduction Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may comprom... Read More

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis (2017)
Journal Article
Amer, S. A., Shamy, T. T. E., James, C., Yosef, A. H., & Mohamed, A. A. (2017). The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis. Reproduction, 154(1), doi:10.1530/REP-17-0063. ISSN 1470-1626

Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian re... Read More

Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women (2017)
Journal Article
Alshammari, G., Khan, R., Brameld, J. M., Amer, S. A., & Lomax, M. A. (2017). Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21(5), ISSN 2284-0729

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory m... Read More

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Mosad, S. M., Khan, R., & Amer, S. (2017). Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells. Toxicology Letters, 272, doi:10.1016/j.toxlet.2017.03.018. ISSN 0378-4274

Background Antipsychotics (APs) are widely prescribed drugs, which are well known to cause reproductive adverse effects through mechanisms yet to be determined. The purpose of this study was to investigate the effect of antipsychotics on mitochond... Read More

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article
Cadagan, D., Khan, R., & Amer, S. A. (2016). Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Reproductive Biology -Olsztyn-, 16(1), doi:10.1016/j.repbio.2015.12.006. ISSN 2300-732X

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion. Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More