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Ovarian reserve after salpingectomy: a systematic review and meta-analysis

Mohamed, Ahmed Aboelfadle; Yosef, Ali Haroun; James, Cathryn; Al-Hussaini, Tarek Khalaf; Bedaiwy, Mohamed Ali; Amer, Saad A.

Authors

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AHMED MOHAMED AHMED.MOHAMED2@NOTTINGHAM.AC.UK
Marie Sklodowska-Curie Early Stage Researcher

Ali Haroun Yosef

Cathryn James

Tarek Khalaf Al-Hussaini

Mohamed Ali Bedaiwy

Saad A. Amer

Abstract

Introduction

Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve.
Material and methods

A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154).
Results

Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, −0.10 ng/mL; 95% CI −0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, −0.11 ng/mL; 95% CI −0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants’ age (

Journal Article Type Article
Publication Date Jun 20, 2017
Journal Acta Obstetricia et Gynecologica Scandinavica
Print ISSN 0001-6349
Electronic ISSN 1600-0412
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 96
Issue 7
Institution Citation Mohamed, A. A., Yosef, A. H., James, C., Al-Hussaini, T. K., Bedaiwy, M. A., & Amer, S. A. (2017). Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 96(7), doi:10.1111/aogs.13133
DOI https://doi.org/10.1111/aogs.13133
Keywords Salpingectomy, Ovarian reserve, Anti-Müllerian hormone, Ovarian function, Laparoscopy
Publisher URL https://doi.org/10.1111/aogs.13133
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: Mohamed AA, Yosef AH, James C, Al-Hussaini TK, Bedaiwy MA, Amer SAKS. Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 2017; 96:795–803., which has been published in final form at https://doi.org/10.1111/aogs.13133. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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