Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment

Corsetti, Maura; Brown, Steven; Chiarioni, Giuseppe; Dimidi, Eirini; Dudding, Thomas; Emmanuel, Anton; Fox, Mark; Ford, Alexander C.; Giordano, Pasquale; Grossi, Ugo; Henderson, Michelle; Knowles, Charles H.; O�Connell, P. Ronan; Quigley, Eamonn M.M.; Simren, Magnus; Spiller, Robin; Whelan, Kevin; Whitehead, William E.; Williams, Andrew B.; Scott, S. Mark

doi:10.1111/nmo.14070

All Outputs (9)

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders (2021)
Journal Article

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined ide... Read More about Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome (2021)
Journal Article

Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanism... Read More about The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.

Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging (2021)
Journal Article

Background: Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well unders... Read More about Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine (2021)
Journal Article

Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammator... Read More about Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine.

Pain severity correlates with biopsy mediated colonic afferent activation but not psychological scores in IBS-D patients (2021)
Journal Article

Objectives: Despite heterogeneity an increased prevalence of psychological co-morbidity and an altered pro-nociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome(IBS). Our aim w... Read More about Pain severity correlates with biopsy mediated colonic afferent activation but not psychological scores in IBS-D patients.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment (2021)
Journal Article

Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment.