All Outputs (16)

Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants (2022)
Journal Article

Migration from one location to another often comes with a change in environmental conditions. Here, we analysed features of DNA methylation in young, adult British-Bangladeshi women who experienced different environments during their childhoods: a) m... Read More about Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants.

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift (2021)
Journal Article

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm) changes. We have identified CG dinucleotides (CpGs) that become continuously hyper- or hypomethylated during long-term culture of mesenchymal stem cells (MSCs) and o... Read More about DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift.

Reply to: Timing of puberty — body size or reproductive optimization? (2021)
Journal Article

Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria (2021)
Journal Article

© 2021, The Author(s). Maximizing crop yields relies on the use of agrochemicals to control insect pests. One of the most widely used classes of insecticides are neonicotinoids that interfere with signalling of the neurotransmitter acetylcholine, but... Read More about Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria.

Unravelling the role of epigenetics in reproductive adaptations to early-life environment (2020)
Journal Article

© 2020, Springer Nature Limited. Reproductive function adjusts in response to environmental conditions in order to optimize success. In humans, this plasticity includes age of pubertal onset, hormone levels and age at menopause. These reproductive ch... Read More about Unravelling the role of epigenetics in reproductive adaptations to early-life environment.

Acute thiamethoxam toxicity in honeybees is not enhanced by common fungicide and herbicide and lacks stress-induced changes in mRNA splicing (2019)
Journal Article

Securing food supply for a growing population is a major challenge and heavily relies on the use of agrochemicals to maximize crop yield. It is increasingly recognized, that some neonicotinoid insecticides have a negative impact on non-target organis... Read More about Acute thiamethoxam toxicity in honeybees is not enhanced by common fungicide and herbicide and lacks stress-induced changes in mRNA splicing.

Editorial: Beyond CpG methylation: New modifications in eukaryotic DNA (2018)
Journal Article

A lexicon of DNA modifications: their roles in embryo development and the germline (2018)
Journal Article

5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are t... Read More about A lexicon of DNA modifications: their roles in embryo development and the germline.

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells (2017)
Journal Article

In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encode... Read More about Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells.

Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with ?-synuclein overexpression and risk of idiopathic Parkinson's disease (2017)
Journal Article

Manganese is an essential trace element however elevated environmental and occupational exposure to this element has been correlated with neurotoxicity symptoms clinically identical to idiopathic Parkinson's disease. In the present study we chronical... Read More about Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with ?-synuclein overexpression and risk of idiopathic Parkinson's disease.

N6-methyldeoxyadenine (6mA) is a Rare Beast - in Animals at Least (retrospective on DOI 10.1002/bies.201500076) (2017)
Journal Article

High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas (2017)
Journal Article

5-methylcytosine (5mC) is a key epigenetic mark which influences gene expression and phenotype. In vertebrates, this epigenetic mark is sensitive to Cd exposure, but there is no information linking such an event with changes in global 5mC levels in t... Read More about High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas.

Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas (2017)
Journal Article

5-Hydroxymethylcytosine (5hmC) is an important, yet poorly understood epigenetic DNA modification, especially in invertebrates. Aberrant genome-wide 5hmC levels have been associated with cadmium (Cd) exposure in humans, but such information is lackin... Read More about Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas.

Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes (2016)
Journal Article

Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulti... Read More about Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes.

A as in actor: A 6mAshing performance (Comment on DOI 10.1002/bies.201500076) (2015)
Journal Article