Qifan Zhu
A lexicon of DNA modifications: their roles in embryo development and the germline
Zhu, Qifan; St�ger, Reinhard; Alberio, Ramiro
Authors
Dr. REINHARD STOGER REINHARD.STOGER@NOTTINGHAM.AC.UK
Associate Professor
RAMIRO ALBERIO ramiro.alberio@nottingham.ac.uk
Professor of Developmental Biology
Abstract
5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are thought to be solely associated with DNA damage. However, growing evidence indicates that some base modifications, namely 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxylcytosine (5caC), and N6-methadenine (6mA), may be of biological relevance, particularly during early stages of embryo development. Although abundance of these DNA modifications in eukaryotic genomes can be low, there are suggestions that they cooperate with other epigenetic markers to affect DNA-protein interactions, gene expression, defense of genome stability and epigenetic inheritance. Little is still known about their distribution in different tissues and their functions during key stages of the animal lifecycle. This review discusses current knowledge and future perspectives of these novel DNA modifications in the mammalian genome with a focus on their dynamic distribution during early embryonic development and their potential function in epigenetic inheritance through the germ line.
Citation
Zhu, Q., Stöger, R., & Alberio, R. (2018). A lexicon of DNA modifications: their roles in embryo development and the germline. Frontiers in Cell and Developmental Biology, 6, Article 24. https://doi.org/10.3389/fcell.2018.00024
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 27, 2018 |
Publication Date | Mar 27, 2018 |
Deposit Date | Apr 5, 2018 |
Publicly Available Date | Apr 5, 2018 |
Journal | Frontiers in Cell and Developmental Biology |
Electronic ISSN | 2296-634X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Article Number | 24 |
DOI | https://doi.org/10.3389/fcell.2018.00024 |
Keywords | Modified bases in eukaryotic DNA; 5mC; 5hmC; 6mA; Germ cells; Embryo; Epigenetic reprogramming |
Public URL | https://nottingham-repository.worktribe.com/output/922020 |
Publisher URL | https://doi.org/10.3389/fcell.2018.00024 |
Files
lexicon fcell-06-00024.pdf
(794 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
In vitro culture of ovine embryos up to early gastrulating stages
(2022)
Journal Article
Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?
(2021)
Journal Article
Nuclear transfer and the development of genetically modified/gene edited livestock
(2021)
Journal Article
Conserved features of non-primate bilaminar disc embryos and the germline
(2021)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search