All Outputs (69)

Panel discussion [of paper: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat] (2008)
Presentation / Conference Contribution
Ivell, R., Hass, U., Anand-Ivell, R., & Gray, E. Panel discussion [of paper: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat]

This is a panel discussion of: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat / S. Christiansen, M. Scholze, M. Axelstad, J. Boberg, A. Kortenkamp, U. Hass.

Summary of main paper:
The incidence... Read More about Panel discussion [of paper: Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat].

Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone" (2007)
Book Chapter
Ivell, R., Heng, K., & Anand-Ivell, R. (2007). Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone". In A. I. Agoulnik (Ed.), Relaxin and Related Peptides (26-33). Springer Verlag. https://doi.org/10.1007/978-0-387-74672-2_3

The small peptide hormone relaxin is a member of a rapidly evolving family of hormones and growth factors, whose mode of action appears to be particularly adapted to purely mammalian physiology. It is representative of a new category of hormones, ref... Read More about Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone".

Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway (2007)
Journal Article
Anand-Ivell, R., Heng, K., Bartsch, O., & Ivell, R. (2007). Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway. Molecular and Cellular Endocrinology, 272(1-2), 1-13. https://doi.org/10.1016/j.mce.2007.04.001

The heterodimeric peptide hormone relaxin acts through the novel G-protein coupled receptor LGR7 to elicit the production of cAMP in the human monocyte cell line THP-1. The very small number of receptors on the cell surface, and the lack of response... Read More about Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway.

Peripheral INSL3 concentrations decline with age in a large population of Australian men (2006)
Journal Article
Anand-Ivell, R., Wohlgemuth, J., Haren, M. T., Hope, P. J., Hatzinikolas, G., Wittert, G., & Ivell, R. (2006). Peripheral INSL3 concentrations decline with age in a large population of Australian men. International Journal of Andrology, 29(6), 618-626. https://doi.org/10.1111/j.1365-2605.2006.00714.x

The novel peptide hormone insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells of the testis, and in adult men is secreted into the blood, giving rise to circulating concentrations ranging from 0.5 to 2.5 ng/mL. We studied... Read More about Peripheral INSL3 concentrations decline with age in a large population of Australian men.

Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis (2006)
Journal Article
Anand-Ivell, R. J., Relan, V., Balvers, M., Coiffec-Dorval, I., Fritsch, M., Bathgate, R. A., & Ivell, R. (2006). Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis. Biology of Reproduction, 74(5), 945-953. https://doi.org/10.1095/biolreprod.105.048165

The new peptide hormone insulin-like peptide 3 (INSL3) is a member of the insulin-relaxin family, yet, unlike insulin, it signals through a new G-protein coupled receptor, LGR8, distantly related to the receptors for LH and FSH. INSL3 is produced in... Read More about Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis.

Relaxin Signaling from Natural Receptors (2006)
Presentation / Conference Contribution
Ivell, R., Anand-Ivell, R., & Bartsch, O. (2004, September). Relaxin Signaling from Natural Receptors. Presented at Relaxin 2004, Fourth International Conference on Relaxin and Related Peptides, Wyoming, USA

The heterodimeric peptide hormone relaxin in most cells appears to signal through a G-protein-coupled receptor, LGR7. Whereas in artificial cell systems, made by transfection of receptor-expressing gene constructs into cells normally not presenting t... Read More about Relaxin Signaling from Natural Receptors.

Constitutive regulation of the Insl3 gene in rat Leydig cells (2005)
Journal Article
Sadeghian, H., Anand-Ivell, R., Balvers, M., Relan, V., & Ivell, R. (2005). Constitutive regulation of the Insl3 gene in rat Leydig cells. Molecular and Cellular Endocrinology, 241(1-2), 10-20. https://doi.org/10.1016/j.mce.2005.03.017

Insulin-like factor 3 (Insl3) is a major new product of the Leydig cells in all mammalian species so far examined. The rat Insl3 gene is encoded by two exons in close juxtaposition to the Jak3 gene. Using RT-PCR analysis we now show that in the rat t... Read More about Constitutive regulation of the Insl3 gene in rat Leydig cells.

Insulin-like factor 3: Where are we now? (2005)
Presentation / Conference Contribution
Ivell, R., Hartung, S., & Anand-Ivell, R. (2004, September). Insulin-like factor 3: Where are we now?. Presented at Relaxin 2004, Fourth International Conference on Relaxin and Related Peptides, Wyoming, USA

Insulin-like factor 3 (INSL3), previously known as the relaxin-like factor (RLF), is a major peptide hormone secreted from the testicular Leydig cells of adult men and circulating in the blood at a concentration of approximately 1 ng/mL. Women also p... Read More about Insulin-like factor 3: Where are we now?.

Understanding relaxin in the female reproductive system (2002)
Journal Article
Ivell, R., & Anand-Ivell, R. (2003). Understanding relaxin in the female reproductive system. Current Medicinal Chemistry Immunology Endocrine and Metabolic Agents, 5(5), 383-389. https://doi.org/10.2174/156801305774322394

Recent advances in our understanding of the hormone relaxin, and the discovery of its specific receptor LGR7, have provided a series of new tools and paradigms, with which to re-examine many aspects of female reproductive physiology classically assoc... Read More about Understanding relaxin in the female reproductive system.