Relaxin Signaling from Natural Receptors

Ivell, Richard; Anand-Ivell, Ravinder; Bartsch, Olaf

Abstract

The heterodimeric peptide hormone relaxin in most cells appears to signal through a G-protein-coupled receptor, LGR7. Whereas in artificial cell systems, made by transfection of receptor-expressing gene constructs into cells normally not presenting the receptor, classic activation of adenylate cyclase appears to be mediated by Gs, in cells naturally expressing the receptor, this type of coupling appears to be very weak. Instead, there is good evidence of other intermediate steps involving cytoplasmic components and tyrosine kinase activity. Part of the complexity of relaxin signaling is also manifest in the variable time course of cAMP production evident in the THP-1 cell line, which appears to depend on passage number and, hence, presumably on differentiation status. It is therefore important to distinguish between immediate early effects, short to mid-term responses, and long-term responses likely the consequences of specific gene upregulation. © 2005 New York Academy of Sciences.

• Journal Article Type: Conference Paper
• Online Publication Date: Jan 9, 2005
• Publication Date: 2005-05
• Deposit Date: Jun 15, 2021
• Journal: Annals of the New York Academy of Sciences
• Print ISSN: 0077-8923
• Electronic ISSN: 1749-6632
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 1041
• Issue: 1
• Pages: 280-287
• DOI: https://doi.org/10.1196/annals.1282.041
• Public URL: https://nottingham-repository.worktribe.com/output/3176639
• Publisher URL: https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1196/annals.1282.041
• Additional Information: Relaxin and Related Peptides: Fourth International Conference