All Outputs (2)

Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone" (2007)
Book Chapter
Ivell, R., Heng, K., & Anand-Ivell, R. (2007). Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone". In A. I. Agoulnik (Ed.), Relaxin and Related Peptides (26-33). Springer Verlag. https://doi.org/10.1007/978-0-387-74672-2_3

The small peptide hormone relaxin is a member of a rapidly evolving family of hormones and growth factors, whose mode of action appears to be particularly adapted to purely mammalian physiology. It is representative of a new category of hormones, ref... Read More about Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone".

Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway (2007)
Journal Article
Anand-Ivell, R., Heng, K., Bartsch, O., & Ivell, R. (2007). Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway. Molecular and Cellular Endocrinology, 272(1-2), 1-13. https://doi.org/10.1016/j.mce.2007.04.001

The heterodimeric peptide hormone relaxin acts through the novel G-protein coupled receptor LGR7 to elicit the production of cAMP in the human monocyte cell line THP-1. The very small number of receptors on the cell surface, and the lack of response... Read More about Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway.