Conserved features of non-primate bilaminar disc embryos and the germline

Alberio, Ramiro; Kobayashi, Toshihiro; Surani, M. Azim

doi:10.1016/j.stemcr.2021.03.011

All Outputs (5)

Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)
Journal Article

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em... Read More about Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.

Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells? (2021)
Journal Article

In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of... Read More about Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Conserved features of non-primate bilaminar disc embryos and the germline (2021)
Journal Article

Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar d... Read More about Conserved features of non-primate bilaminar disc embryos and the germline.