All Outputs (18)

Interpretable Multi-Task Conditional Neural Networks Reveal Cancer Cell Adhesion Characteristics From Phonon Microscopy Images (2025)
Journal Article
Zheng, Y., Fuentes-Dominguez, R., Goni, M. R., Clark, M., Gordon, G. S., & Perez-Cota, F. (2025). Interpretable Multi-Task Conditional Neural Networks Reveal Cancer Cell Adhesion Characteristics From Phonon Microscopy Images. IEEE Journal of Biomedical and Health Informatics, 1-11. https://doi.org/10.1109/jbhi.2025.3556599

Advances in artificial intelligence (AI) show significant promise in multiscale modeling and biomedical informatics, particularly in the analysis of phonon microscopy (high-frequency ultrasound) data for cancer detection. This study addresses critica... Read More about Interpretable Multi-Task Conditional Neural Networks Reveal Cancer Cell Adhesion Characteristics From Phonon Microscopy Images.

Body wave to surface wave conversion using tailored meta-structures (2025)
Journal Article
Fuentes-Domínguez, R., Smith, R. J., Jin, P., Simonelli, M., Gibbon, S., & Clark, M. (2025). Body wave to surface wave conversion using tailored meta-structures. Journal of Sound and Vibration, 603, Article 118989. https://doi.org/10.1016/j.jsv.2025.118989

Elastic waves are important in many application areas. Their manipulation and coupling between different acoustic modes is important and presents a considerable challenge that offers to unlock the flexibility in wave transport required for efficient... Read More about Body wave to surface wave conversion using tailored meta-structures.

Optoacoustic lenses for lateral sub-optical resolution elasticity imaging (2024)
Journal Article
Yao, M., Fuentes-Dominguez, R., La Cavera III, S., Perez-Cota, F., Smith, R. J., & Clark, M. (2025). Optoacoustic lenses for lateral sub-optical resolution elasticity imaging. Photoacoustics, 41, Article 100663. https://doi.org/10.1016/j.pacs.2024.100663

In this paper, we demonstrate for the first time the focusing of gigahertz coherent phonon pulses propagating in water using picosecond ultrasonics and Brillouin light scattering. We achieve this by using planar Fresnel zone plate and concave lenses... Read More about Optoacoustic lenses for lateral sub-optical resolution elasticity imaging.

Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology (2024)
Journal Article
La Cavera, S., Chauhan, V. M., Hardiman, W., Yao, M., Fuentes-Domínguez, R., Setchfield, K., Abayzeed, S. A., Pérez-Cota, F., Smith, R. J., & Clark, M. (2024). Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology. Communications Biology, 7(1), Article 451. https://doi.org/10.1038/s42003-024-06126-4

This report presents an optical fibre-based endo-microscopic imaging tool that simultaneously measures the topographic profile and 3D viscoelastic properties of biological specimens through the phenomenon of time-resolved Brillouin scattering. This u... Read More about Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology.

Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning (2023)
Journal Article
Pérez-Cota, F., Martínez-Arellano, G., La Cavera III, S., Hardiman, W., Thornton, L., Fuentes-Domínguez, R., Smith, R. J., McIntyre, A., & Clark, M. (2023). Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning. Scientific Reports, 13, Article 16228. https://doi.org/10.1038/s41598-023-42793-9

There is a consensus about the strong correlation between the elasticity of cells and tissue and their normal, dysplastic, and cancerous states. However, developments in cell mechanics have not seen significant progress in clinical applications. In t... Read More about Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning.

Parallel imaging with phonon microscopy using a multi-core fibre bundle detection (2023)
Journal Article
Fuentes-Domínguez, R., Yao, M., Hardiman, W., La Cavera III, S., Setchfield, K., Pérez-Cota, F., Smith, R. J., & Clark, M. (2023). Parallel imaging with phonon microscopy using a multi-core fibre bundle detection. Photoacoustics, 31, Article 100493. https://doi.org/10.1016/j.pacs.2023.100493

In this paper, we show a proof-of-concept method to parallelise phonon microscopy measurements for cell elasticity imaging by demonstrating a 3-fold increase in acquisition speed which is limited by current acquisition hardware. Phonon microscopy is... Read More about Parallel imaging with phonon microscopy using a multi-core fibre bundle detection.

Diffractive metasurface light-shaping from fiber endoscope probes for increased depth of field (2023)
Presentation / Conference Contribution
He, F., Gordon, G., Fuentes-Dominguez, R., Cousins, R., Mellor, C. J., Barton, J. . K., & Gordon, G. S. . D. (2023, January). Diffractive metasurface light-shaping from fiber endoscope probes for increased depth of field. Presented at Endoscopic Microscopy XVIII, San Francisco, USA

In applications such as optical coherence tomography, there is a need both to achieve large depth of field by light shaping and to maintain ultracompact form factors. Flat metasurfaces on optical fibers can achieve such requirements, with designs suc... Read More about Diffractive metasurface light-shaping from fiber endoscope probes for increased depth of field.

Polarization-Sensitive Super-Resolution Phononic Reconstruction of Nanostructures (2022)
Journal Article
Fuentes-Domínguez, R., Naznin, S., La Cavera III, S., Cousins, R., Pérez-Cota, F., Smith, R. J., & Clark, M. (2022). Polarization-Sensitive Super-Resolution Phononic Reconstruction of Nanostructures. ACS Photonics, https://doi.org/10.1021/acsphotonics.1c01607

In this paper, we show for the first time the polarization-sensitive super-resolution phononic reconstruction of multiple nanostructures in a liquid environment by overcoming the diffraction limit of the optical system (1 μm). By using time-resolved... Read More about Polarization-Sensitive Super-Resolution Phononic Reconstruction of Nanostructures.

Transfering ultra-Thin metallic metasurfaces to fibre endoscope probes for advanced imaging (2022)
Presentation / Conference Contribution
Fuentes-Dominguez, R., He, F., Cousins, R., Mellor, C. J., & Gordon, G. S. D. (2022, January). Transfering ultra-Thin metallic metasurfaces to fibre endoscope probes for advanced imaging. Presented at SPIE Photonics West 2022, San Francisco, California, USA

In this paper we present a method to transfer ultra-Thin polymer-encapsulated metallic metasurfaces onto optical fibers to enable ultra-Thin imaging devices. The metasurface is first produced by conventional e-beam lithography on a silicon substrate... Read More about Transfering ultra-Thin metallic metasurfaces to fibre endoscope probes for advanced imaging.

Measurement of the single crystal elasticity matrix of polycrystalline materials (2021)
Journal Article
Dryburgh, P., Li, W., Pieris, D., Fuentes-Domínguez, R., Patel, R., Smith, R. J., & Clark, M. (2022). Measurement of the single crystal elasticity matrix of polycrystalline materials. Acta Materialia, 225, Article 117551. https://doi.org/10.1016/j.actamat.2021.117551

Many engineering metals are polycrystalline, as such the elasticity, crystalline orientation and grain distribution are cardinal factors in determining the physical properties of the material. The grain distribution can be measured using a number of... Read More about Measurement of the single crystal elasticity matrix of polycrystalline materials.

Design of a resonant Luneburg lens for surface acoustic waves (2020)
Journal Article
Fuentes-Domínguez, R., Yao, M., Colombi, A., Dryburgh, P., Pieris, D., Jackson-Crisp, A., Colquitt, D., Clare, A., Smith, R. J., & Clark, M. (2021). Design of a resonant Luneburg lens for surface acoustic waves. Ultrasonics, 111, Article 106306. https://doi.org/10.1016/j.ultras.2020.106306

© 2020 In this work we employ additive manufacturing to print a circular array of micropillars on an aluminium slab turning its top surface into a graded index metasurface for surface acoustic waves (SAW). The graded metasurface reproduces a Luneburg... Read More about Design of a resonant Luneburg lens for surface acoustic waves.

Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells (2020)
Journal Article
Pérez-Cota, F., Fuentes-Domínguez, R., La Cavera III, S., Hardiman, W., Yao, M., Setchfield, K., Moradi, E., Naznin, S., Wright, A., Webb, K. F., Huett, A., Friel, C., Sottile, V., Elsheikha, H. M., Smith, R. J., & Clark, M. (2020). Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells. Journal of Applied Physics, 128(16), Article 160902. https://doi.org/10.1063/5.0023744

© 2020 Author(s). Characterization of the elasticity of biological cells is growing as a new way to gain insight into cell biology. Cell mechanics are related to most aspects of cellular behavior, and applications in research and medicine are broad.... Read More about Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells.

Tailored elastic surface to body wave Umklapp conversion (2020)
Journal Article
Chaplain, G. J., De Ponti, J. M., Colombi, A., Fuentes-Dominguez, R., Dryburg, P., Pieris, D., Smith, R. J., Clare, A., Clark, M., & Craster, R. V. (2020). Tailored elastic surface to body wave Umklapp conversion. Nature Communications, 11(1), Article 3267. https://doi.org/10.1038/s41467-020-17021-x

© 2020, The Author(s). Elastic waves guided along surfaces dominate applications in geophysics, ultrasonic inspection, mechanical vibration, and surface acoustic wave devices; precise manipulation of surface Rayleigh waves and their coupling with pol... Read More about Tailored elastic surface to body wave Umklapp conversion.

Characterising the size and shape of metallic nano-structures by their acoustic vibrations (2020)
Journal Article
Fuentes-Domínguez, R., Naznin, S., Marques, L., Pérez-Cota, F., Smith, R. J., & Clark, M. (2020). Characterising the size and shape of metallic nano-structures by their acoustic vibrations. Nanoscale, 12(26), 14230-14236. https://doi.org/10.1039/d0nr03410j

© 2020 The Royal Society of Chemistry. The characterisation of metallic nano-structures is of great importance as their optical properties are strongly dependent on their size and shape. Inaccurate size or shape characterisation can result in mislead... Read More about Characterising the size and shape of metallic nano-structures by their acoustic vibrations.

Apparent attenuation by opto-acoustic defocus in phonon microscopy (2020)
Journal Article
Fuentes-Domínguez, R., La Cavera, S., Pérez-Cota, F., La Cavera III, S., Naznin, S., Fuentes-Dominguez, R., Smith, R. J., & Clark, M. (2020). Apparent attenuation by opto-acoustic defocus in phonon microscopy. Photoacoustics, 19, Article 100180. https://doi.org/10.1016/j.pacs.2020.100180

© 2020 The Author(s) Understanding the mechanical properties of biological cells is a challenging problem for the life sciences partly because there are limited methods for mapping elasticity with high resolution. Phonon microscopy is a form of Brill... Read More about Apparent attenuation by opto-acoustic defocus in phonon microscopy.

Time resolved Brillouin fiber-spectrometer (2019)
Journal Article
La Cavera, S., Pérez-Cota, F., Fuentes-Domínguez, R., Smith, R. J., & Clark, M. (2019). Time resolved Brillouin fiber-spectrometer. Optics Express, 27(18), 25064-25071. https://doi.org/10.1364/OE.27.025064

This report introduces a novel time resolved Brillouin spectrometer, consisting of an opto-acoustic transducer which resides on the tip of a single-mode optical fiber of arbitrary length with 125 µm outer diameter and 5 µm sensing diameter. Demonstra... Read More about Time resolved Brillouin fiber-spectrometer.

Super-resolution imaging using nano-bells (2018)
Journal Article
Fuentes-Dominguez, R., Pérez-Cota, F., Naznin, S., Smith, R. J., & Clark, M. (2018). Super-resolution imaging using nano-bells. Scientific Reports, 8, 1-9. https://doi.org/10.1038/s41598-018-34744-6

In this paper we demonstrate a new scheme for optical super-resolution, inspired, in-part, by PALM and STORM. In this scheme each object in the field of view is tagged with a signal that allows them to be detected separately. By doing this we can ide... Read More about Super-resolution imaging using nano-bells.

Wireless bioelectronic nanosystems for intracellular communication (2018)
Other
Sanjuán-Alberte, P., Abayzeed, S. A., Fuentes-Domínguez, R., Alea-Reyesd, M. E., Clark, M., Hague, R., Alexander, M., Pérez-García, L., & Rawson, F. (2018). Wireless bioelectronic nanosystems for intracellular communication

In order for the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of “wireless” electronic systems to both sense and actuate cell behaviour. Herein we report the first example of an innovativ... Read More about Wireless bioelectronic nanosystems for intracellular communication.