All Outputs (4)

Time-gated Raman spectroscopy for biomedical application under ambient or strong background light conditions (2021)
Journal Article
Corden, C., Boitor, R., & Notingher, I. (2021). Time-gated Raman spectroscopy for biomedical application under ambient or strong background light conditions. Journal of Physics D: Applied Physics, 54(50), Article 504003. https://doi.org/10.1088/1361-6463/ac276e

Many biomedical applications require measurements of Raman spectra of tissue under ambient lighting conditions. However, the background light often swamps the weaker Raman signal. The use of time-gated (TG) Raman spectroscopy based on a single photon... Read More about Time-gated Raman spectroscopy for biomedical application under ambient or strong background light conditions.

Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery (2021)
Journal Article
Lizio, M. G., Boitor, R., & Notingher, I. (2021). Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery. Analyst, 146(12), 3799-3809. https://doi.org/10.1039/d1an00296a

One of the main challenges in cancer surgery is to ensure the complete excision of the tumour while sparing as much healthy tissue as possible. Histopathology, the gold-standard technique used to assess the surgical margins on the excised tissue, is... Read More about Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery.

Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma (2021)
Journal Article
Boitor, R., de Wolf, C., Weesie, F., Shipp, D. W., Varma, S., Veitch, D., …Notingher, I. (2021). Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. Biomedical Optics Express, 12(4), 2015-2026. https://doi.org/10.1364/boe.417896

We present the first clinical integration of a prototype device based on integrated auto-fluorescence imaging and Raman spectroscopy (Fast Raman device) for intra-operative assessment of surgical margins during Mohs micrographic surgery of basal cell... Read More about Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma.

Combined total internal reflection AF spectral-imaging and Raman spectroscopy for fast assessment of surgical margins during breast cancer surgery (2021)
Journal Article
Lizio, M. G., Liao, Z., Shipp, D. W., Boitor, R., Mihai, R., Sharp, J. S., …Notingher, I. (2021). Combined total internal reflection AF spectral-imaging and Raman spectroscopy for fast assessment of surgical margins during breast cancer surgery. Biomedical Optics Express, 12(2), 940-954. https://doi.org/10.1364/boe.411648

The standard treatment for breast cancer is surgical removal mainly through breast conserving surgey (BCS). We developed a new technique based on auto-fluorescence (AF) spectral imaging and Raman spectroscopy for fast intraoperative assessment of exc... Read More about Combined total internal reflection AF spectral-imaging and Raman spectroscopy for fast assessment of surgical margins during breast cancer surgery.