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All Outputs (14)

Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach (2023)
Journal Article
Nweze, T., Banaschewski, T., Ajaelu, C., Okoye, C., Ezenwa, M., Whelan, R., …IMAGEN Consortium. (2023). Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach. Journal of Child Psychology and Psychiatry, 64(8), 1159-1175. https://doi.org/10.1111/jcpp.13793

Background: Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferen... Read More about Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach.

Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use (2022)
Journal Article
Perkins, E. R., Joyner, K. J., Foell, J., Drislane, L. E., Brislin, S. J., Frick, P. J., …Consortium, T. I. (2022). Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use. Journal of Psychopathology and Clinical Science, 131(7), 793-807. https://doi.org/10.1037/abn0000743

This study explored the generality versus specificity of two trait-liability factors for externalizing problems — disinhibition and callousness — in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperact... Read More about Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use.

Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence (2022)
Journal Article
Nees, F., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Grigis, A., Garavan, H., …on behalf of the IMAGEN Consortium. (2022). Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence. Brain Sciences, 12(9), Article 1187. https://doi.org/10.3390/brainsci12091187

Background: Autistic traits are commonly viewed as dimensional in nature, and as continuously distributed in the general population. In this respect, the identification of predictive values of markers such as subtle autism-related alterations in brai... Read More about Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence.

A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood (2022)
Journal Article
Kaiser, A., Holz, N. E., Banaschewski, T., Baumeister, S., Bokde, A. L. W., Desrivières, S., …Nees, F. (2022). A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(11), 1103-1115. https://doi.org/10.1016/j.bpsc.2022.02.003

Background: On a theoretical level, impulsivity represents a multidimensional construct associated with acting without foresight, inefficient inhibitory response control, and alterations in reward processing. On an empirical level, relationships and... Read More about A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., …Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts (2021)
Journal Article
Elkrief, L., Spinney, S., Vosberg, D. E., Banaschewski, T., Bokde, A., Quinlan, E. B., …Conrod, P. (2021). Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts. Frontiers in Psychiatry, 12, Article 645746. https://doi.org/10.3389/fpsyt.2021.645746

Genetic markers of endocannabinoid system have been linked to a variety of addiction-related behaviours that extend beyond cannabis use. In the current study we investigate the relationship between eCB genetic markers and AUDs in European adolescents... Read More about Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., …Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors (2020)
Journal Article
Zhang, Z., Robinson, L., Jia, T., Quinlan, E. B., Tay, N., Chu, C., …Desrivières, S. (2021). Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors. Biological Psychiatry, 90(12), 853-862. https://doi.org/10.1016/j.biopsych.2020.06.003

BACKGROUND:
Eating disorders are common in adolescence, devastating and strongly comorbid with other psychiatric disorders. Yet, little is known about their etiology to develop effective preventive measures.

METHODS:
Longitudinal assessments of... Read More about Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors.

Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy (2020)
Journal Article
Khalaf, A., Hoad, C. L., Blackshaw, E., Alyami, J., Spiller, R. C., Gowland, P. A., …Marciani, L. (2020). Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy. Diagnostics, 10(3), Article 170. https://doi.org/10.3390/diagnostics10030170

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS sh... Read More about Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy.

Cortical thickness and formal thought disorder in schizophrenia: An ultra high-field network-based morphometry study (2020)
Journal Article
Palaniyappan, L., Al-Radaideh, A., Gowland, P. A., & Liddle, P. F. (2020). Cortical thickness and formal thought disorder in schizophrenia: An ultra high-field network-based morphometry study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 101, Article 109911. https://doi.org/10.1016/j.pnpbp.2020.109911

Background

Persistent formal thought disorder (FTD) is a core feature of schizophrenia. Recent cognitive and neuroimaging studies indicate a distinct mechanistic pathway underlying the persistent positive FTD (pFTD or disorganized thinking), thoug... Read More about Cortical thickness and formal thought disorder in schizophrenia: An ultra high-field network-based morphometry study.

Human hippocampal CA3 damage disrupts both recent and remote episodic memories (2020)
Journal Article
Miller, T. D., Chong, T. T.-J., Aimola Davies, A. M., Johnson, M. R., Irani, S. R., Husain, M., …Rosenthal, C. R. (2020). Human hippocampal CA3 damage disrupts both recent and remote episodic memories. eLife, 2020(9), Article 41836. https://doi.org/10.7554/elife.41836

Neocortical-hippocampal interactions support new episodic (event) memories, but there is conflicting evidence about the dependence of remote episodic memories on the hippocampus. In line with systems consolidation and computational theories of episod... Read More about Human hippocampal CA3 damage disrupts both recent and remote episodic memories.

Identification of neurobehavioural symptom groups based on shared brain mechanisms (2019)
Journal Article
Ing, A., Sӓmann, P. G., Chu, C., Tay, N., Biondo, F., Jia, T., …IMAGEN Consortium. (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour, 3, 1306–1318. https://doi.org/10.1038/s41562-019-0738-8

Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural sympt... Read More about Identification of neurobehavioural symptom groups based on shared brain mechanisms.

Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis (2018)
Journal Article
Drury, R. J., Falah, Y., Gowland, P. A., Evangelou, N., Bright, M. G., & Francis, S. T. (2019). Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis. European Radiology, 29(4), 2027–2033. https://doi.org/10.1007/s00330-018-5707-5

Objectives

Assess the feasibility of using an optimised ultra-high-field high-spatial-resolution low-distortion ASL MRI acquisition to measure focal haemodynamic pathology in cortical lesions (CLs) in Multiple Sclerosis (MS).

Methods

Twelve... Read More about Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis.