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Two spatially distinct posterior alpha sources fulfill different functional roles in attention (2019)
Journal Article
Sokoliuk, R., Mayhew, S., Aquino, K., Wilson, R., Brookes, M., Francis, S., …Mullinger, K. (2019). Two spatially distinct posterior alpha sources fulfill different functional roles in attention. Journal of Neuroscience, 39(36), 7183-7194. https://doi.org/10.1523/jneurosci.1993-18.2019

Directing attention helps extracting relevant information and suppressing distracters. Alpha brain oscillations (8-12Hz) are crucial for this process, with power decreases facilitating processing of important information and power increases inhibitin... Read More

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging (2019)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B., Taal, M. W., …Francis, S. T. (2019). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfz129

Background Multiparametric Magnetic Resonance Imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated... Read More

Increased fasting small bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging (2019)
Journal Article
Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., …Spiller, R. (2019). Increased fasting small bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal, doi:10.1177/2050640619860372

Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC... Read More

Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography (2019)
Journal Article
Tierney, T. M., Holmes, N., Mellor, S., López, J. D., Roberts, G., Hill, R. M., …Barnes, G. R. (2019). Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography. NeuroImage, 199, 598-608. doi:10.1016/j.neuroimage.2019.05.063

Optically Pumped Magnetometers (OPMs) have emerged as a viable and wearable alternative to cryogenic, superconducting MEG systems. This new generation of sensors has the advantage of not requiring cryogenic cooling and as a result can be flexibly pla... Read More

A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis (2019)
Journal Article
Murray, K., Hoad, C., Garratt, J., Kaviani, M., Marciani, L., Smith, J., …Spiller, R. (2019). A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis. PLoS ONE, 14(5), doi:10.1371/journal.pone.0216528

Background Complications of diverticular disease are increasingly common, possibly linked to increasing obesity. Visceral fat could contribute to the development of symptomatic diverticular disease through its pro-inflammatory effects. Objective... Read More

The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group (2019)
Journal Article
Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., …Corsetti, M. (2019). The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences, 134, 31-59. doi:10.1016/j.ejps.2019.04.003

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of th... Read More

MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury (2019)
Journal Article
Lawrence, T. P., Steel, A., Ezra, M., Speirs, M., Pretorius, P. M., Douaud, G., …Voets, N. L. (2019). MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury. Brain Injury, doi:10.1080/02699052.2019.1584332

The posterior cingulate cortex (PCC) and corpus callosum (CC) are susceptible to trauma, but injury often evades detection. PCC Metabolic disruption may predict CC white matter tract injury and the secondary cascade responsible for progression. While... Read More

Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation (2019)
Journal Article
Xing, Y., Tench, C., Wongwandee, M., Schwarz, S., Bajaj, N., & Auer, D. (2019). Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation. Brain Imaging and Behavior, doi:10.1007/s11682-019-00061-3

Objective To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson’s (PwP), aiming to differentiate disease-specific features from treatment effects. Methods A co-ordinate-based-meta-analysis (CBMA... Read More

Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon (2019)
Journal Article
(in press). Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon. Neurogastroenterology and Motility, doi:10.1111/nmo.13557

Background: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal... Read More

Using GPUs to accelerate computational diffusion MRI: from microstructure estimation to tractography and connectomes (2018)
Journal Article
Hernandez-Fernandez, M., Reguly, I., Jbabdi, S., Giles, M., Smith, S., & Sotiropoulos, S. N. (2019). Using GPUs to accelerate computational diffusion MRI: from microstructure estimation to tractography and connectomes. NeuroImage, 188, 598-615. doi:10.1016/j.neuroimage.2018.12.015

The great potential of computational diffusion MRI (dMRI) relies on indirect inference of tissue microstructure and brain connections, since modelling and tractography frameworks map diffusion measurements to neuroanatomical features. This mapping ho... Read More

Addressing challenges of high spatial resolution, UHF fMRI for group analysis of higher-order cognitive tasks; an inter-sensory task directing attention between visual and somatosensory domains (2018)
Journal Article
Aquino, K., Sokoliuk, R., Pakenham, D., Sanchez, R., Hanslmayr, S., Mayhew, S., …Francis, S. (2019). Addressing challenges of high spatial resolution, UHF fMRI for group analysis of higher-order cognitive tasks; an inter-sensory task directing attention between visual and somatosensory domains. Human Brain Mapping, 40(4), 1298-1316. doi:10.1002/hbm.24450

Functional MRI at ultra-high field (UHF, ≥7T) provides significant increases in BOLD contrast-to-noise ratio (CNR) compared with conventional field strength (3T), and has been exploited for reduced field-of-view, high spatial resolution mapping of pr... Read More

Lifespan pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI (2018)
Journal Article
Xing, Y., Sapuan, A., Dineen, R., & Auer, D. P. (2018). Lifespan pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI. Movement Disorders, 33(11), 1792-1799. doi:10.1002/mds.27502

Background: Neuromelanin is a pigment with strong iron-chelating properties preferentially found in dopaminergic neurons of the substantia nigra, pars compacta (SNpc). Parkinson's disease is characterized by pronounced, MRI detectable neuromelanin lo... Read More

How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes (2018)
Journal Article
Tewarie, P., Abeysuriya, R., Byrne, Á., O'Neill, G. C., Sotioropoulos, S. N., Brookes, M. J., & Coombes, S. (2019). How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes. NeuroImage, 186, 211-220. doi:10.1016/j.neuroimage.2018.10.079

Functional networks obtained from magnetoencephalography (MEG) from different frequency bands show distinct spatial patterns. It remains to be elucidated how distinct spatial patterns in MEG networks emerge given a single underlying structural networ... Read More

Exploring the relative efficacy of motion artefact correction techniques for EEG data acquired during simultaneous fMRI (2018)
Journal Article
Alexander, D. J., Smith, J. A., Spencer, G. S., Jorge, J., Bowtell, R., & Mullinger, K. J. (2019). Exploring the relative efficacy of motion artefact correction techniques for EEG data acquired during simultaneous fMRI. Human Brain Mapping, 40(2), 578-596. doi:10.1002/hbm.24396

Simultaneous EEG-fMRI allows multi-parametric characterisation of brain function, in principle enabling a more complete understanding of brain responses; unfortunately the hostile MRI environment severely reduces EEG data quality. Simply eliminating... Read More

The Noise Exposure Structured Interview (NESI): an instrument for the comprehensive estimation of lifetime noise exposure (2018)
Journal Article
Guest, H., Dewey, R. S., Plack, C. J., Couth, S., Prendergast, G., Bakay, W., & Hall, D. A. (2018). The Noise Exposure Structured Interview (NESI): an instrument for the comprehensive estimation of lifetime noise exposure. Trends in Hearing, 22, 1-10. doi:10.1177/2331216518803213

Lifetime noise exposure is generally quantified by self report. The accuracy of retrospective self report is limited by respondent recall, but is also bound to be influenced by reporting procedures. Such procedures are of variable quality in current... Read More

Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis (2018)
Journal Article
Drury, R. J., Falah, Y., Gowland, P. A., Evangelou, N., Bright, M. G., & Francis, S. T. (2019). Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis. European Radiology, 29(4), 2027–2033

Objectives Assess the feasibility of using an optimised ultra-high-field high-spatial-resolution low-distortion ASL MRI acquisition to measure focal haemodynamic pathology in cortical lesions (CLs) in Multiple Sclerosis (MS). Methods Twelve... Read More

Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR (2018)
Journal Article
Xiao, D., Xu, S., Brownbill, N. J., Paul, S., Chen, L., Pawsey, S., …Blanc, F. (2018). Fast detection and structural identification of carbocations on zeolites by dynamic nuclear polarization enhanced solid-state NMR. Chemical Science, 9(43), 8184-8193. doi:10.1039/c8sc03848a

Acidic zeolites are porous aluminosilicates used in a wide range of industrial processes such as adsorption and catalysis. The formation of carbocation intermediates plays a key role in reactivity, selectivity and deactivation in heterogeneous cataly... Read More

Magnetic resonance imaging on sodium nuclei: potential medical applications of 23Na MRI (2018)
Journal Article
Sadykhov, E., Pirogov, Y., Anisimov, N., Gulyaev, M., Pavlovskaya, G., Meersmann, T., …Fomina, D. (2018). Magnetic resonance imaging on sodium nuclei: potential medical applications of 23Na MRI. Applied Magnetic Resonance, 925-957. doi:10.1007/s00723-018-1045-7

Sodium is a key element in a living organism. The increase of its concentration is an indicator of many pathological conditions. 23Na magnetic resonance imaging (MRI) is a quantitative method that allows to determine the sodium content in tissues and... Read More

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), doi:10.1371/journal.pone.0201410. ISSN 1932-6203

Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More