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Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors

Zhang, Zuo; Robinson, Lauren; Jia, Tianye; Quinlan, Erin Burke; Tay, Nicole; Chu, Congying; Barker, Edward D.; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Stringaris, Argyris; Penttil�, Jani; van Noort, Betteke; Grimmer, Yvonne; Paill�re Martinot, Marie-Laure; Isensee, Corinna; Becker, Andreas; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tom�; Poustka, Luise; Hohmann, Sarah; Fr�hner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Schmidt, Ulrike; Desrivi�res, Sylvane

Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors Thumbnail


Authors

Zuo Zhang

Lauren Robinson

Tianye Jia

Erin Burke Quinlan

Nicole Tay

Congying Chu

Edward D. Barker

Tobias Banaschewski

Gareth J. Barker

Arun L.W. Bokde

Herta Flor

Antoine Grigis

Hugh Garavan

Andreas Heinz

Bernd Ittermann

Jean-Luc Martinot

Argyris Stringaris

Jani Penttil�

Betteke van Noort

Yvonne Grimmer

Marie-Laure Paill�re Martinot

Corinna Isensee

Andreas Becker

Frauke Nees

Dimitri Papadopoulos Orfanos

Tom� Paus

Luise Poustka

Sarah Hohmann

Juliane H. Fr�hner

Michael N. Smolka

Henrik Walter

Robert Whelan

Gunter Schumann

Ulrike Schmidt

Sylvane Desrivi�res



Abstract

BACKGROUND:
Eating disorders are common in adolescence, devastating and strongly comorbid with other psychiatric disorders. Yet, little is known about their etiology to develop effective preventive measures.

METHODS:
Longitudinal assessments of disordered eating behaviors (DEBs; binge-eating, purging and dieting) and comorbid psychopathology were measured in 1,386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems were investigated by comparing participants who reported symptoms at ages 16 or 19, but not at age 14 to asymptomatic controls. Voxel-based morphometry and psychopathological differences at age 14 were investigated to identify risk factors for the development of DEBs and associated mental health problems.

RESULTS:
DEBs and depressive symptoms developed together. Emotional and behavioral problems, including symptoms of attention deficit hyperactivity disorder (ADHD) and conduct disorder (CD), predated their development. Alterations in fronto-striatal brain areas also predated the development of DEBs and depressive symptoms. Specifically, development of binge-eating was predicted by higher grey matter volumes in the right putamen/globus pallidus at age 14. Conversely, development of purging and depressive symptoms was predicted by lower volumes in the medial orbitofrontal, dorsomedial and dorsolateral prefrontal cortices. Lower grey matter volumes in the orbitofrontal and anterior cingulate cortices mediated the relationship between ADHD and CD symptoms and future purging and depressive symptoms.

CONCLUSIONS:
These findings suggest that alterations in frontal brain circuits are part of the shared etiology between eating disorders, ADHD, CD and depression and highlight the importance of a transdiagnostic approach to treating these conditions.
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Citation

Zhang, Z., Robinson, L., Jia, T., Quinlan, E. B., Tay, N., Chu, C., …Desrivières, S. (2021). Development of Disordered Eating Behaviors and Comorbid Depressive Symptoms in Adolescence: Neural and Psychopathological Predictors. Biological Psychiatry, 90(12), 853-862. https://doi.org/10.1016/j.biopsych.2020.06.003

Journal Article Type Article
Acceptance Date Jun 1, 2020
Online Publication Date Jun 10, 2020
Publication Date Dec 15, 2021
Deposit Date Jun 8, 2020
Publicly Available Date Mar 28, 2024
Journal Biological Psychiatry
Print ISSN 0006-3223
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 90
Issue 12
Pages 853-862
DOI https://doi.org/10.1016/j.biopsych.2020.06.003
Keywords eating disorders, depression, attention deficit hyperactivity disorder, conduct disorder, biomarkers, grey matter volume
Public URL https://nottingham-repository.worktribe.com/output/4605704
Publisher URL https://www.sciencedirect.com/science/article/pii/S0006322320316723?via%3Dihub

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