Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach

Nweze, Tochukwu; Banaschewski, Tobias; Ajaelu, Cyracius; Okoye, Chukwuemeka; Ezenwa, Michael; Whelan, Robert; Papadopoulos Orfanos, Dimitri; Bokde, Arun L.W.; Desrivières, Sylvane; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean‐Luc; Martinot, Marie‐Laure Paillère; Artiges, Eric; Nees, Frauke; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Millenet, Sabina; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Schumann, Gunter; Hanson, Jamie L.; IMAGEN Consortium

Abstract

Background: Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods: Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations – assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results: Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. β = −.327, p =.042, 95% CI [−0.643, −0.012]) and right anterior cingulate surface area (Std. β = −.274, p =.038, 95% CI [−0.533, −0.015]) across ages 14–22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion: Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted.

Citation

Nweze, T., Banaschewski, T., Ajaelu, C., Okoye, C., Ezenwa, M., Whelan, R., Papadopoulos Orfanos, D., Bokde, A. L., Desrivières, S., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J., Martinot, M. P., Artiges, E., Nees, F., Paus, T., Poustka, L., …IMAGEN Consortium. (2023). Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach. Journal of Child Psychology and Psychiatry, 64(8), 1159-1175. https://doi.org/10.1111/jcpp.13793

• Journal Article Type: Article
• Acceptance Date: Mar 13, 2023
• Online Publication Date: Mar 29, 2023
• Publication Date: 2023-08
• Deposit Date: Apr 28, 2023
• Publicly Available Date: May 2, 2023
• Journal: Journal of Child Psychology and Psychiatry
• Print ISSN: 0021-9630
• Electronic ISSN: 1469-7610
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 8
• Pages: 1159-1175
• DOI: https://doi.org/10.1111/jcpp.13793
• Keywords: Stress, cortical development, cognitive functioning, longitudinal models, bivariate latent change score model, longitudinal mediation analysis
• Public URL: https://nottingham-repository.worktribe.com/output/19287159
• Publisher URL: https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.13793