Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy

Khalaf, Asseel; Hoad, Caroline L.; Blackshaw, Elaine; Alyami, Jaber; Spiller, Robin C.; Gowland, Penny A.; Vinayaka-Moorthy, Vidhiya; Perkins, Alan C.; Moran, Gordon W.; Marciani, Luca

Abstract

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS showed good correlation, but were performed on separate study days. In this study, the modalities were alternated rapidly allowing direct comparison with no intra-individual variability confounds. Twelve healthy participants consumed 400 g of Technetium-99m (99mTc)-labelled soup test meal (204 kcal) and were imaged at intervals for 150 min, alternating between MRI and GS. The time to empty half of the stomach contents (T1/2) and retention rate (RR) were calculated and data correlated. The average T1/2 was similar for MRI (44 ± 6 min) and GS (35 ± 4 min) with a moderate but significant difference between the two modalities (p ≤0.004). The individual T1/2 values were measured, and MRI and GS showed a good positive correlation (r = 0.95, p ≤ 0.0001), as well as all the RRs at each time point up to 120 min. Gastric emptying was measured for the first time by MRI and GS on the same day. This may help with translating the use of this simple meal, known to elicit reliable, physiological, and pathological gastrointestinal motor, peptide, and appetite responses

Citation

Khalaf, A., Hoad, C. L., Blackshaw, E., Alyami, J., Spiller, R. C., Gowland, P. A., Vinayaka-Moorthy, V., Perkins, A. C., Moran, G. W., & Marciani, L. (2020). Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy. Diagnostics, 10(3), Article 170. https://doi.org/10.3390/diagnostics10030170

• Journal Article Type: Article
• Acceptance Date: Mar 17, 2020
• Online Publication Date: Mar 22, 2020
• Publication Date: Mar 22, 2020
• Deposit Date: Mar 23, 2020
• Publicly Available Date: Mar 23, 2020
• Journal: Diagnostics
• Electronic ISSN: 2075-4418
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 3
• Article Number: 170
• DOI: https://doi.org/10.3390/diagnostics10030170
• Keywords: Magnetic resonance imaging; Stomach; Validation; Volumes; Half emptying; Activity
• Public URL: https://nottingham-repository.worktribe.com/output/4193322
• Publisher URL: https://www.mdpi.com/2075-4418/10/3/170