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Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy

Khalaf, Asseel; Hoad, Caroline L.; Blackshaw, Elaine; Alyami, Jaber; Spiller, Robin C.; Gowland, Penny A.; Vinayaka-Moorthy, Vidhiya; Perkins, Alan C.; Moran, Gordon W.; Marciani, Luca

Authors

Asseel Khalaf

Elaine Blackshaw

Jaber Alyami

ROBIN SPILLER ROBIN.SPILLER@NOTTINGHAM.AC.UK
Professor of Gastroenterology

Vidhiya Vinayaka-Moorthy

Alan C. Perkins

GORDON MORAN Gordon.Moran@nottingham.ac.uk
Clinical Associate Professor

LUCA MARCIANI LUCA.MARCIANI@NOTTINGHAM.AC.UK
Professor of Gastrointestinal Imaging



Abstract

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS showed good correlation, but were performed on separate study days. In this study, the modalities were alternated rapidly allowing direct comparison with no intra-individual variability confounds. Twelve healthy participants consumed 400 g of Technetium-99m (99mTc)-labelled soup test meal (204 kcal) and were imaged at intervals for 150 min, alternating between MRI and GS. The time to empty half of the stomach contents (T1/2) and retention rate (RR) were calculated and data correlated. The average T1/2 was similar for MRI (44 ± 6 min) and GS (35 ± 4 min) with a moderate but significant difference between the two modalities (p ≤0.004). The individual T1/2 values were measured, and MRI and GS showed a good positive correlation (r = 0.95, p ≤ 0.0001), as well as all the RRs at each time point up to 120 min. Gastric emptying was measured for the first time by MRI and GS on the same day. This may help with translating the use of this simple meal, known to elicit reliable, physiological, and pathological gastrointestinal motor, peptide, and appetite responses

Citation

Khalaf, A., Hoad, C. L., Blackshaw, E., Alyami, J., Spiller, R. C., Gowland, P. A., …Marciani, L. (2020). Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy. Diagnostics, 10(3), https://doi.org/10.3390/diagnostics10030170

Journal Article Type Article
Acceptance Date Mar 17, 2020
Online Publication Date Mar 22, 2020
Publication Date Mar 22, 2020
Deposit Date Mar 23, 2020
Publicly Available Date Mar 23, 2020
Journal Diagnostics
Electronic ISSN 2075-4418
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 10
Issue 3
Article Number 170
DOI https://doi.org/10.3390/diagnostics10030170
Keywords Magnetic resonance imaging; Stomach; Validation; Volumes; Half emptying; Activity
Public URL https://nottingham-repository.worktribe.com/output/4193322
Publisher URL https://www.mdpi.com/2075-4418/10/3/170