Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain

Brookes, Alice; Jewell, Adelaide; Feng, Wanshan; Bradshaw, Tracey D.; Butler, James; Gershkovich, Pavel

doi:10.1016/j.ijpharm.2023.122651

All Outputs (3)

Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport (2023)
Journal Article

The establishment of latent cellular and anatomical viral reservoirs is a major obstacle to achieving a cure for people infected by HIV. Mesenteric lymph nodes (MLNs) are one of the most important anatomical reservoirs of HIV. Suboptimal levels of an... Read More about Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport.

Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain (2023)
Journal Article

We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD f... Read More about Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain.

Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain (2023)
Journal Article

Delivery to the brain is a challenging task due to its protection by the blood–brain barrier (BBB). Lipids and fatty acids are reported to affect the permeability of the BBB, although this has not been reported following oral administration. Cannabid... Read More about Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain.