Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays

Lee, Jong Bong; Zgair, Atheer; Taha, Dhiaa A.; Zang, Xiaowei; Kagan, Leonid; Kim, Tae Hwan; Kim, Min Gi; Yun, Hwi-yeol; Fischer, Peter M.; Gershkovich, Pavel

doi:10.1016/j.ejpb.2016.12.027

All Outputs (4)

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation (2017)
Journal Article

Cannabidiol (CBD) and ?9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoids with lipids can substantially increa... Read More about Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

Development of cordycepin formulations for preclinical and clinical studies (2017)
Journal Article

There is extensive literature on in vivo studies with cordycepin but these studies were generally conducted without validation of the various formulations, especially in terms of the solubility of cordycepin in the dosing vehicles used. Cordycepin is... Read More about Development of cordycepin formulations for preclinical and clinical studies.

Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity (2017)
Journal Article

The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid-base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles. The... Read More about Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity.

Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays (2017)
Journal Article

In this study, Caco-2 permeability results from different laboratories were compared. Six different sets of apparent permeability coefficient (Papp) values reported in the literature were compared to experimental Papp obtained in our laboratory. The... Read More about Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.