Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation

Hashmani, Khurram; Branch, Matthew James; Sidney, Laura E.; Dhillon, Permesh Singh; Verma, Megha; McIntosh, Owen Douglas; Hopkinson, Andrew; Dua, Harminder Singh

doi:10.1186/scrt226

All Outputs (4)

Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane (2019)
Journal Article

© 2019, The Author(s). Amniotic membrane (AM) is used to treat a range of ophthalmic indications but must be presented in a non-contaminated state. AM from elective caesarean sections contains natural microbial contamination, requiring removal during... Read More about Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane.

Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model (2019)
Journal Article

BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells (hCEC). AIM To investigate whether corneal-stroma derived stem cells (CSSC) seeded on an amniotic membrane (AM) construct m... Read More about Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model.

Phenotypic change and induction of cytokeratin expression during in vitro culture of corneal stromal cells (2015)
Journal Article

Purpose: Cells of the corneal epithelium and stroma can be distinguished in vivo by different intermediate filaments, cytokeratins for corneal epithelial cells (CEC) and vimentin for keratocytes. Isolated and cultured keratocytes change phenotype, lo... Read More about Phenotypic change and induction of cytokeratin expression during in vitro culture of corneal stromal cells.

Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation (2013)
Journal Article

Introduction: The corneal stroma is being increasingly recognized as a repository for stem cells. Like the limbal and endothelial niches, stromal stem cells often reside in the peripheral cornea and limbus. These peripheral and limbal corneal stromal... Read More about Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation.