All Outputs (7)

The role of flagella in Clostridium difficile pathogenesis:comparison between a non-epidemic and an epidemicstrain (2013)
Journal Article

Clostridium difficile is a major cause of healthcare-associated infection and inflicts a considerable financial burden on healthcare systems worldwide. Disease symptoms range from self-limiting diarrhoea to fatal pseudomembranous colitis. Whilst C. d... Read More about The role of flagella in Clostridium difficile pathogenesis:comparison between a non-epidemic and an epidemicstrain.

Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824 (2013)
Journal Article

BACKGROUND: Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation of released sugars into valuable products such as butanol. Clostridial species that produce butanol are, h... Read More about Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824.

Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain (2013)
Journal Article

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To deve... Read More about Importance of Toxin A, Toxin B, and CDT in virulence of an epidemic Clostridium difficile strain.

Clostridium difficile modulates host innate immunity via toxin-independent and dependent mechanism(s) (2013)
Journal Article

Clostridium difficile infection (CDI) is the leading cause of hospital and community-acquired antibiotic-associated diarrhoea and currently represents a significant health burden. Although the role and contribution of C. difficile toxins to disease p... Read More about Clostridium difficile modulates host innate immunity via toxin-independent and dependent mechanism(s).

The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum (2013)
Journal Article

The bacterium Clostridium acetobutylicum produces acids as an energy-yielding process during exponential growth. An acidic environment, however, is toxic to the cells and two survival mechanisms are in place to prevent them from dying. Firstly, durin... Read More about The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum.

Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles (2013)
Journal Article

Sophisticated genetic tools to modify essential biological processes at the molecular level are pivotal in elucidating the molecular pathogenesis of Clostridium difficile, a major cause of healthcare associated disease. Here we have developed an effi... Read More about Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles.

Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile (2013)
Journal Article

Bacteria within biofilms are protected from multiple stresses, including immune responses and antimicrobial agents. The biofilm-forming ability of bacterial pathogens has been associated with increased antibiotic resistance and chronic recurrent infe... Read More about Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile.