Research Repository

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Multiparametric measurement of cerebral physiology using calibrated fMRI (2017)
Journal Article
Bright, M. G., Croal, P. L., Blockley, N. P., & Bulte, D. P. (2017). Multiparametric measurement of cerebral physiology using calibrated fMRI. NeuroImage, doi:10.1016/j.neuroimage.2017.12.049

The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO2), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO2, m... Read More

Gas-free calibrated fMRI with a correction for vessel-size sensitivity (2017)
Journal Article
Berman, A. J., Mazerolle, E. L., MacDonald, M. E., Blockley, N. P., Luh, W., & Pike, G. B. (2018). Gas-free calibrated fMRI with a correction for vessel-size sensitivity. NeuroImage, 169, 176-188. doi:10.1016/j.neuroimage.2017.12.047

Calibrated functional magnetic resonance imaging (fMRI) is a method to independently measure the metabolic and hemodynamic contributions to the blood oxygenation level dependent (BOLD) signal. This technique typically requires the use of a respirator... Read More

Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired (2017)
Journal Article
Blockley, N. P., Harkin, J. W., & Bulte, D. P. (2017). Rapid cerebrovascular reactivity mapping: Enabling vascular reactivity information to be routinely acquired. NeuroImage, 159, 214-223. doi:10.1016/j.neuroimage.2017.07.048

Cerebrovascular reactivity mapping (CVR), using magnetic resonance imaging (MRI) and carbon dioxide as a stimulus, provides useful information on how cerebral blood vessels react under stress. This information has proven to be useful in the study of... Read More

Improving the specificity of R2′ to the deoxyhaemoglobin content of brain tissue: Prospective correction of macroscopic magnetic field gradients (2016)
Journal Article
Blockley, N. P., & Stone, A. J. (2016). Improving the specificity of R2′ to the deoxyhaemoglobin content of brain tissue: Prospective correction of macroscopic magnetic field gradients. NeuroImage, 135, 253-260. doi:10.1016/j.neuroimage.2016.04.013

The reversible transverse relaxation rate, R2′, is sensitive to the deoxyhaemoglobin content of brain tissue, enabling information about the oxygen extraction fraction to be obtained. However, R2′ is also sensitive to macroscopic magnetic field gradi... Read More

A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations (2016)
Journal Article
Simon, A. B., Dubowitz, D. J., Blockley, N. P., & Buxton, R. B. (2016). A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations. NeuroImage, 129, 198-213. doi:10.1016/j.neuroimage.2016.01.001

Calibrated blood oxygenation level dependent (BOLD) imaging is a multimodal functional MRI technique designed to estimate changes in cerebral oxygen metabolism from measured changes in cerebral blood flow and the BOLD signal. This technique addresses... Read More

Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T (2015)
Journal Article
Driver, I. D., Andoh, J., Blockley, N. P., Francis, S. T., Gowland, P. A., & Paus, T. (2015). Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T. NMR in Biomedicine, 28(5), 538-545. doi:10.1002/nbm.3282

Current functional MRI (fMRI) approaches assess underlying neuronal activity through monitoring the related local variations in cerebral blood oxygenation, blood volume and blood flow. This vascular response is likely to vary across brain regions and... Read More