Multiparametric measurement of cerebral physiology using calibrated fMRI

Bright, Molly G.; Croal, Paula L.; Blockley, Nicholas P.; Bulte, Daniel P.

doi:10.1016/j.neuroimage.2017.12.049

Authors

Molly G. Bright

Paula L. Croal

NIC BLOCKLEY Nicholas.Blockley@nottingham.ac.uk
Assistant Professor

Daniel P. Bulte

Abstract

The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO2), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO2, many other physiological parameters of interest are often acquired along the way. This can significantly increase the value of the dataset, providing greater information that is clinically relevant, or detail that can disambiguate the cause of signal variations. This can also be somewhat of a double-edged sword: calibrated fMRI experiments combine multiple parameters into a physiological model that requires multiple steps, thereby providing more opportunity for error propagation and increasing the noise and error of the final derived values. As with all measurements, there is a trade-off between imaging time, spatial resolution, coverage, and accuracy. In this review, we provide a brief overview of the benefits and pitfalls of extracting multiparametric measurements of cerebral physiology through calibrated fMRI experiments.

Citation

Bright, M. G., Croal, P. L., Blockley, N. P., & Bulte, D. P. (2019). Multiparametric measurement of cerebral physiology using calibrated fMRI. NeuroImage, 187, 128-144. https://doi.org/10.1016/j.neuroimage.2017.12.049

Journal Article Type	Article
Acceptance Date	Dec 15, 2017
Online Publication Date	Dec 19, 2017
Publication Date	Feb 15, 2019
Deposit Date	Dec 10, 2018
Publicly Available Date	Dec 20, 2018
Journal	NeuroImage
Print ISSN	1053-8119
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	187
Pages	128-144
DOI	https://doi.org/10.1016/j.neuroimage.2017.12.049
Keywords	Cognitive Neuroscience; Neurology
Public URL	https://nottingham-repository.worktribe.com/output/1313122
Publisher URL	https://www.sciencedirect.com/science/article/pii/S105381191731073X