Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach

Stone, Alan J.; Harston, George W. J.; Carone, Davide; Okell, Thomas W.; Kennedy, James; Blockley, Nicholas P.

doi:10.1002/hbm.24564

Authors

Alan J. Stone

George W. J. Harston

Davide Carone

Thomas W. Okell

James Kennedy

NIC BLOCKLEY Nicholas.Blockley@nottingham.ac.uk
Assistant Professor

Abstract

Metabolic markers of baseline brain oxygenation and tissue perfusion have an important role to play in the early identification of ischaemic tissue in acute stroke. Although well established MRI techniques exist for mapping brain perfusion, quantitative imaging of brain oxygenation is poorly served. Streamlined?qBOLD (sqBOLD) is a recently developed technique for mapping oxygenation that is well suited to the challenge of investigating acute stroke. In this study a noninvasive serial imaging protocol was implemented, incorporating sqBOLD and arterial spin labelling to map blood oxygenation and perfusion, respectively. The utility of these parameters was investigated using imaging based definitions of tissue outcome (ischaemic core, infarct growth and contralateral tissue). Voxel wise analysis revealed significant differences between all tissue outcomes using pairwise comparisons for the transverse reversible relaxation rate (R 2?), deoxygenated blood volume (DBV) and deoxyghaemoglobin concentration ([dHb]; p

Citation

Stone, A. J., Harston, G. W. J., Carone, D., Okell, T. W., Kennedy, J., & Blockley, N. P. (2019). Prospects for investigating brain oxygenation in acute stroke: experience with a non-contrast quantitative BOLD based approach. Human Brain Mapping, 40(10), 2853-2866. https://doi.org/10.1002/hbm.24564

Journal Article Type	Article
Acceptance Date	Feb 26, 2019
Online Publication Date	Mar 12, 2019
Publication Date	Mar 12, 2019
Deposit Date	Apr 30, 2019
Publicly Available Date	May 1, 2019
Journal	Human Brain Mapping
Print ISSN	1065-9471
Electronic ISSN	1097-0193
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	40
Issue	10
Pages	2853-2866
DOI	https://doi.org/10.1002/hbm.24564
Keywords	Anatomy; Radiological and ultrasound technology; Radiology nuclear medicine and imaging; Neurology; Clinical neurology
Public URL	https://nottingham-repository.worktribe.com/output/1884112