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Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology?specific outcome taxonomy (2020)
Journal Article

Background: Standardized outcome reporting is crucial for trial evidence synthesis and translation of findings into clinical decision making. The OMERACT 2.0 Filter and COMET outcome domain taxonomy propose frameworks for consistent reporting of outc... Read More about Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology?specific outcome taxonomy.

Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP) (2019)
Journal Article

Background: Eczema control has been identified as an important outcome by key stakeholders in eczema research (including patients, carers, healthcare professionals and researchers) but no validated instruments for the domain have been identified. Obj... Read More about Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP).

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors (2019)
Journal Article

© 2019 British Association of Dermatologists This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It presents the key findings from 14 sy... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors.

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention (2019)
Journal Article

© 2019 British Association of Dermatologists This review is part of a series of annual updates summarizing the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed durin... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention.

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 3: nomenclature and outcome assessment (2019)
Journal Article

© 2019 British Association of Dermatologists This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It presents the key findings from 11 systematic reviews published in 2016 that focus on AE outc... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 3: nomenclature and outcome assessment.

Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article

Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More about Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable.

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment (2018)
Journal Article

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 26 systematic reviews that were published... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 2: prevention and treatment.

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2018)
Journal Article

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus... Read More about Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology (2018)
Journal Article

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology.

What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention (2016)
Journal Article

This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It provides a summary of key findings from 12 systematic reviews (SRs) that were published or indexed during 2014, and focuses on the treatm... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 2. Treatment and prevention.

What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes (2016)
Journal Article

This review summarizes key findings from nine systematic reviews on atopic eczema (AE) published or first indexed in 2014. It focuses on epidemiology, disease processes and methodological issues. There is reasonable evidence to conclude that high bir... Read More about What's new in atopic eczema? An analysis of systematic reviews published in 2014. Part 1. Epidemiology, risk factors and outcomes.

What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials (2016)
Journal Article

Atopic eczema (AE) is a common chronic inflammatory skin condition. Whilst many AE treatment options are available, the evidence to support their efficacy varies in depth and quality. In 2000, an NIHR HTA systematic review identified and evaluated ex... Read More about What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials.

Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma (2014)
Journal Article

Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix metalloproteinase-1 (MMP-1) is present in remodelled airways but its re... Read More about Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma.