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All Outputs (34)

Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods (2015)
Journal Article
Jung, D. S., Crowe, J. A., Birchall, J. P., Somekh, M. G., & See, C. W. (2015). Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods. Biomedical Optics Express, 6(10), 3820-3825. https://doi.org/10.1364/BOE.6.003820

The ability to monitor the inflammatory state of the middle ear mucosa would provide clinical utility. To enable spectral measurements on the mucosa whilst rejecting background signal from the eardrum an anti-confocal system is investigated. In contr... Read More about Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods.

Monte Carlo photon simulation of an anti-confocal system to monitor middle ear inflammation (2015)
Presentation / Conference Contribution
Jung, D. S., Birchall, J. P., Crowe, J. A., See, C. W., & Somekh, M. G. (2015, April). Monte Carlo photon simulation of an anti-confocal system to monitor middle ear inflammation. Presented at OMP 2015 Optical Molecular Probes, Imaging and Drug Delivery, Vancouver, Canada

Monte Carlo simulations of an anti-confocal system to monitor middle ear inflammation showed that using a stop to reject the scattering plane, the eardrum, rather than a pinhole to select the imaging plane, improved the signal-to-background ratio.

Rapid wide-field heterodyne interferometry with custom 2D CMOS camera (2015)
Journal Article
Zhang, J., See, C. W., Smith, R. J., Johnston, N. S., Pitter, M. C., Somekh, M. G., & Light, R. A. (2015). Rapid wide-field heterodyne interferometry with custom 2D CMOS camera. Electronics Letters, 51(6), 479-480. https://doi.org/10.1049/el.2015.0268

© The Institution of Engineering and Technology 2015. A wide-field pseudo-heterodyne interference contrast microscope is described, which employs a complementary metal-oxide semiconductor (CMOS) phase-sensitive camera. The use of multiple wells in th... Read More about Rapid wide-field heterodyne interferometry with custom 2D CMOS camera.

Optically excited nanoscale ultrasonic transducers (2015)
Journal Article
Smith, R. J., Cota, F. P., Marques, L., Chen, X., Arca, A., Webb, K., Aylott, J. W., Somekh, M. G., & Clark, M. (2015). Optically excited nanoscale ultrasonic transducers. Journal of the Acoustical Society of America, 137(1), 219-227. https://doi.org/10.1121/1.4904487

© 2015 Acoustical Society of America. In order to work at higher ultrasonic frequencies, for instance, to increase the resolution, it is necessary to fabricate smaller and higher frequency transducers. This paper presents an ultrasonic transducer cap... Read More about Optically excited nanoscale ultrasonic transducers.

Sub-100 nm resolution microscopy based on proximity projection grating scheme (2015)
Journal Article
Hu, F., Somekh, M. G., Albutt, D. J., Webb, K., Moradi, E., & See, C. W. (2015). Sub-100 nm resolution microscopy based on proximity projection grating scheme. Scientific Reports, 5, Article 8589. https://doi.org/10.1038/srep08589

Structured illumination microscopy (SIM) has been widely used in life science imaging applications. The maximum resolution improvement of SIM, compared to conventional bright field system is a factor of 2. Here we present an approach to structured il... Read More about Sub-100 nm resolution microscopy based on proximity projection grating scheme.

Highly sensitive multipoint real-time kinetic detection of Surface Plasmon bioanalytes with custom CMOS cameras (2014)
Journal Article
Wang, J., Smith, R. J., Light, R. A., Richens, J. L., Zhang, J., O'Shea, P., See, C., & Somekh, M. G. (2014). Highly sensitive multipoint real-time kinetic detection of Surface Plasmon bioanalytes with custom CMOS cameras. Biosensors and Bioelectronics, 58, 157-164. https://doi.org/10.1016/j.bios.2014.02.042

Phase sensitive Surface Plasmon Resonance (SPR) techniques are a popular means of characterizing biomolecular interactions. However, limitations due to the narrow dynamic range and difficulty in adapting the method for multi-point sensing have restri... Read More about Highly sensitive multipoint real-time kinetic detection of Surface Plasmon bioanalytes with custom CMOS cameras.

Ultrastable embedded surface plasmon confocal interferometry (2014)
Journal Article
Pechprasarn, S., Zhang, B., Albutt, D., Zhang, J., & Somekh, M. (2014). Ultrastable embedded surface plasmon confocal interferometry. Light: Science and Applications, 3(7), Article e187. https://doi.org/10.1038/lsa.2014.68

As disease diagnosis becomes more sophisticated, there is a requirement to measure small numbers of molecules attached to, for instance, an antibody. This requires a sensor capable not only of high sensitivity but also the ability to make measurement... Read More about Ultrastable embedded surface plasmon confocal interferometry.

Surface plasmon microscopic sensing with beam profile modulation (2012)
Journal Article
Zhang, B., Pechprasarn, S., & Somekh, M. G. (2012). Surface plasmon microscopic sensing with beam profile modulation. Optics Express, 20(27), https://doi.org/10.1364/OE.20.028039

Surface Plasmon microscopy enables measurement of local refractive index on a far finer scale than prism based systems. An interferometric or confocal system gives the so-called V(z) curve when the sample is scanned axially, which gives a measure of... Read More about Surface plasmon microscopic sensing with beam profile modulation.

Determination of crystallographic orientation of large grain metals with surface acoustic waves (2012)
Journal Article
Li, W., Sharples, S. D., Smith, R. J., Clark, M., & Somekh, M. G. (2012). Determination of crystallographic orientation of large grain metals with surface acoustic waves. Journal of the Acoustical Society of America, 132(2), 738-745. https://doi.org/10.1121/1.4731226

A previously described laser ultrasonic technique known as spatially resolved acoustic spectroscopy (SRAS) can be used to image surface microstructure, using the local surface acoustic wave (SAW) velocity as a contrast mechanism. It is shown here tha... Read More about Determination of crystallographic orientation of large grain metals with surface acoustic waves.

Confocal surface plasmon microscopy with pupil function engineering (2012)
Journal Article
Zhang, B., Pechprasarn, S., Zhang, J., & Somekh, M. G. (2012). Confocal surface plasmon microscopy with pupil function engineering. Optics Express, 20(7), https://doi.org/10.1364/OE.20.007388

Surface Plasmon microscopy can measure local changes of refractive index on the micron scale. Interferometric plasmon imaging delivers quantitative high spatial resolution sensitive to refractive index. In addition the so called V(z) method allows im... Read More about Confocal surface plasmon microscopy with pupil function engineering.

CHOTs optical transducers (2011)
Journal Article
Arca, A., Aylott, J., Marques, L., Clark, M., Somekh, M., Smith, R., Sharples, S., Stratoudaki, T., & Chen, X. (2011). CHOTs optical transducers. Nondestructive Testing and Evaluation, 26(3-4), 353-366. https://doi.org/10.1080/10589759.2011.573555

Laser ultrasonics conventionally use direct absorption in the sample to generate ultrasound and monitor the sample to detect the ultrasound. However, in some circumstances there are significant advantages to using an optical transducer - a device to... Read More about CHOTs optical transducers.

The Design of a Real Time VLSI Optical Centroid Processor (2002)
Presentation / Conference Contribution
Pui, B. H., Hayes-Gill, B., Clark, M., Somekh, M., See, C., Morgan, S., & Ng, A. (2002, June). The Design of a Real Time VLSI Optical Centroid Processor. Presented at IEEE International Conference on Sensors 2002, Orlando, Florida, USA

A real time VLSI optical centroid processor has been developed as part of a larger Shack-Hartmann wavefront sensor system for applications in adaptive optics. The implementation of the optical centroid detection system was demonstrated successfully u... Read More about The Design of a Real Time VLSI Optical Centroid Processor.

The design and characterisation of an optical VLSI processor for real time centroid detection (2001)
Presentation / Conference Contribution
Boon Hean Pui, Hayes-Gill, B., Clark, M., Somekh, M., See, C., Piéri, J. F., Morgan, S., & Ng, A. (2001, April). The design and characterisation of an optical VLSI processor for real time centroid detection. Presented at Design, Test, Integration, and Packaging of MEMS/MOEMS 2001, 2001, Cannes-Mandelieu, France

The integration of photo-detectors onto a standard CMOS integrated circuit is presented. This device provides the optical front end for a real time centroid detection system to be used as part of a larger system for implementing a Shack-Hartmann wave... Read More about The design and characterisation of an optical VLSI processor for real time centroid detection.