Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA)

N� Leidhin, Caoilfhionn; McMorrow, Jason; Carey, Daniel; Newman, Louise; Williamson, Wilby; Fagan, Andrew J.; Chappell, Michael A.; Kenny, Rose Anne; Meaney, James F.; Knight, Silvin P.

doi:10.1016/j.neuroimage.2021.117741

All Outputs (5)

Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model (2021)
Journal Article

Purpose In this paper, the ability to quantify cerebral blood flow by arterial spin labeling (ASL) was studied by investigating the separation of the macrovascular and tissue component using a 2-component model. Underlying assumptions of this model,... Read More about Validation of the estimation of the macrovascular contribution in multi‐timepoint arterial spin labeling MRI using a 2‐component kinetic model.

Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far? (2021)
Journal Article

The mismatch in the spatial resolution of Arterial Spin Labeling (ASL) MRI perfusion images and the anatomy of functionally distinct tissues in the brain leads to a partial volume effect (PVE), which in turn confounds the estimation of perfusion into... Read More about Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?.

Examination of optimized protocols for pCASL: Sensitivity to macrovascular contamination, flow dispersion, and prolonged arterial transit time (2021)
Journal Article

Purpose Previously, multi- post-labeling delays (PLD) pseudo-continuous arterial spin labeling (pCASL) protocols have been optimized for the estimation accuracy of the cerebral blood flow (CBF) with/without the arterial transit time (ATT) under a st... Read More about Examination of optimized protocols for pCASL: Sensitivity to macrovascular contamination, flow dispersion, and prolonged arterial transit time.

Study Protocol: The Heart and Brain Study (2021)
Journal Article

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA) (2021)
Journal Article

Objective To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Backgroun... Read More about Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA).