All Outputs (38)

Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling (2019)
Journal Article

Purpose Multi‐phase PCASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labeling plane. However, there exists a bias in the estimation process that is a function of noise in the dat... Read More about Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling.

Model-based Bayesian inference of brain oxygenation using quantitative BOLD (2019)
Journal Article

© 2019 The Authors Streamlined Quantitative BOLD (sqBOLD) is an MR technique that can non-invasively measure physiological parameters including Oxygen Extraction Fraction (OEF) and deoxygenated blood volume (DBV) in the brain. Current sqBOLD methodol... Read More about Model-based Bayesian inference of brain oxygenation using quantitative BOLD.

ICA-based denoising for ASL perfusion imaging (2019)
Journal Article

Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in the brain. As the image generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routi... Read More about ICA-based denoising for ASL perfusion imaging.

Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages (2019)
Journal Article

© 2019 AMA. All rights reserved. Importance: Poor cardiovascular health is an established risk factor for dementia, but little is known about its association with brain physiology in older adults. Objective: To examine the association of cardiovascul... Read More about Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages.

High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging (2019)
Journal Article

Purpose The goal of this study was to achieve high temporal resolution, multi?time point pseudo?continuous arterial spin labeling (pCASL) MRI in a time?efficient manner, while maintaining whole?brain coverage. Methods A Hadamard 8?matrix was use... Read More about High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.

Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging (2019)
Journal Article

Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet multiple facto... Read More about Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging.

A general framework for optimizing arterial spin labeling MRI experiments (2018)
Journal Article

Purpose Arterial spin labeling (ASL) MRI is a non‐invasive perfusion imaging technique that is inherently SNR limited, so scan protocols ideally need to be rigorously optimized to provide the most accurate measurements. A general framework is presen... Read More about A general framework for optimizing arterial spin labeling MRI experiments.

Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework (2018)
Journal Article

The estimation of myocardial blood flow (MBF) in dynamic PET can be biased by many different processes. A major source of error, particularly in clinical applications, is patient motion. Patient motion, or gross motion, creates displacements between... Read More about Assessing Reliability of Myocardial Blood Flow After Motion Correction With Dynamic PET Using a Bayesian Framework.

Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice (2018)
Journal Article

Brain and tumour blood flow can be measured noninvasively using arterial spin labelling (ASL) magnetic resonance imaging (MRI), but reliable quantification in mouse models remains difficult. Pseudocontinuous ASL (pCASL) is recommended as the clinical... Read More about Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice.

4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties (2018)
Journal Article

Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging (2018)
Journal Article

A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth (2017)
Journal Article

Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular... Read More about A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.

The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging (2017)
Journal Article

A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI (2017)
Journal Article

Arterial spin labeling (ASL) MRI is a non-invasive technique for the quantification of cerebral perfusion, and pseudo-continuous arterial spin labeling (PCASL) has been recommended as the standard implementation by a recent consensus of the community... Read More about A systematic study of the sensitivity of partial volume correction methods for the quantification of perfusion from pseudo-continuous arterial spin labeling MRI.

Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease (2017)
Journal Article

Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular... Read More about Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease.

Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience (2017)
Journal Article

The different results from flat panel detector CT in various pathologies have provoked some discussion. Our aim was to assess the role of flat panel detector CT in brain arteriovenous malformations, which has not yet been assessed. Five patients with... Read More about Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience.

Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling (2016)
Journal Article

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging (2014)
Journal Article

© 2014 The Author. The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imagi... Read More about Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.