All Outputs (5)

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the ?-Opioid Receptor (2015)
Journal Article
Schembri, L. S., Stoddart, L. A., Briddon, S. J., Kellam, B., Canals, M., Graham, B., & Scammells, P. J. (2015). Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the ?-Opioid Receptor. Journal of Medicinal Chemistry, 58(24), 9754-9767. https://doi.org/10.1021/acs.jmedchem.5b01664

Fluorescently labeled ligands are useful pharmacological research tools for studying receptor localization, trafficking, and signaling processes via fluorescence imaging. They are also employed in fluorescent binding assays. This study is centered on... Read More about Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the ?-Opioid Receptor.

The complex roles of ?-opioid receptor phosphorylation: A key determinant in receptor signaling and regulation (2015)
Journal Article
Canals, M. (2015). The complex roles of ?-opioid receptor phosphorylation: A key determinant in receptor signaling and regulation. Molecular Pharmacology, 88(4), 814-815. https://doi.org/10.1124/mol.115.100180

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. This Commentary focuses on two articles in the October 2015 issue of Molecular Pharmacology that investigate the role of μ-opioid receptor phosphorylation in rec... Read More about The complex roles of ?-opioid receptor phosphorylation: A key determinant in receptor signaling and regulation.

Biased Agonism of Endogenous Opioid Peptides at the ?-Opioid Receptor (2015)
Journal Article
Thompson, G. L., Lane, J. R., Coudrat, T., Sexton, P. M., Christopoulos, A., & Canals, M. (2015). Biased Agonism of Endogenous Opioid Peptides at the ?-Opioid Receptor. Molecular Pharmacology, 88(2), 335-346. https://doi.org/10.1124/mol.115.098848

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. Biased agonism is having a major impact on modern drug discovery, and describes the ability of distinct G protein-coupled receptor (GPCR) ligands to activate dif... Read More about Biased Agonism of Endogenous Opioid Peptides at the ?-Opioid Receptor.

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the ?-opioid receptor (2015)
Journal Article
Burford, N. T., Livingston, K. E., Canals, M., Ryan, M. R., Budenholzer, L., Han, Y., …Alt, A. (2015). Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. Journal of Medicinal Chemistry, 58(10), 4220-4229. https://doi.org/10.1021/acs.jmedchem.5b00007

© 2015 American Chemical Society. Allosteric modulators of G protein-coupled receptors (GPCRs) have a number of potential advantages compared to agonists or antagonists that bind to the orthosteric site of the receptor. These include the potential fo... Read More about Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the ?-opioid receptor.

Detection and quantifi cation of intracellular signaling using fret-based biosensors and high content imaging (2015)
Book Chapter
Halls, M. L., Poole, D. P., Ellisdon, A. M., Nowell, C. J., & Canals, M. (2015). Detection and quantifi cation of intracellular signaling using fret-based biosensors and high content imaging. In G Protein-Coupled Receptors in Drug Discovery, (131-161). (2nd). Humana Press. https://doi.org/10.1007/978-1-4939-2914-6_10

© Springer Science+Business Media New York 2015. Förster resonance energy transfer (FRET) biosensors represent invaluable tools to detect the spatiotemporal context of second messenger production and intracellular signaling that cannot be attained us... Read More about Detection and quantifi cation of intracellular signaling using fret-based biosensors and high content imaging.