Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
(2017)
Journal Article
Yarwood, R., Imlach, W., Lieu, T., Veldhuis, N., Jensen, D., Herenbrink, C., …Bunnett, N. (2017). Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Proceedings of the National Academy of Sciences, 114(46), 12309-12314. https://doi.org/10.1073/pnas.1706656114
G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals. Consequently, therapeutic drugs are designed... Read More about Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.