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Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Halls, M.L.; Canals, M.


M.L. Halls


Genetically encoded Förster resonance energy transfer (FRET) biosensors have been instrumental to our understanding of how intracellular signalling is organised and regulated within cells. In the last decade, the toolbox, dynamic range and applications of these sensors have expanded beyond basic cell biology applications. In particular, FRET biosensors have shed light onto the mechanisms that control the intracellular organisation of G protein-coupled receptor (GPCR) signalling and have allowed the visualisation of signalling events with unprecedented temporal and spatial resolution. Here we review the use of these sensors in the GPCR field and how it has already provided invaluable advances towards our understanding of the complexity of GPCR signalling. © 2017 Elsevier Ltd


Halls, M., & Canals, M. (2018). Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling. Trends in Pharmacological Sciences, 39(2), 148-157.

Journal Article Type Article
Acceptance Date Oct 17, 2017
Online Publication Date Oct 17, 2017
Publication Date 2018-02
Deposit Date Jan 17, 2020
Print ISSN 0165-6147
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 39
Issue 2
Pages 148-157
Keywords compartmentalised signalling; Förster resonance energy transfer biosensors; G protein-coupled receptor; G protein coupled receptor; recombinant protein; animal; cell compartmentalization; chemistry; fluorescence resonance energy transfer; genetic procedu
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