All Outputs (8)

A review of experimental models of focal cerebral ischemia focusing on the middle cerebral artery occlusion model (2021)
Journal Article

Cerebral ischemic stroke is a leading cause of death and disability, but current pharmacological therapies are limited in their utility and effectiveness. In vitro and in vivo models of ischemic stroke have been developed which allow us to further el... Read More about A review of experimental models of focal cerebral ischemia focusing on the middle cerebral artery occlusion model.

Longitudinal Multimodal fMRI to Investigate Neurovascular Changes in Spontaneously Hypertensive Rats (2020)
Journal Article

Hypertension is an important risk factor for age?related cognitive decline and neuronal pathologies. Studies have shown a correlation between hypertension, disruption in neurovascular coupling and cerebral autoregulation, and cognitive decline. Howev... Read More about Longitudinal Multimodal fMRI to Investigate Neurovascular Changes in Spontaneously Hypertensive Rats.

A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain (2020)
Journal Article

As the population ages, the incidence of age-related neurological diseases and cognitive decline increases. To further understand disease-related changes in brain function it is advantageous to examine brain activity changes in healthy aging rodent m... Read More about A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.

Improved reperfusion following alternative surgical approach for experimental stroke in mice (2020)
Journal Article

Improved reperfusion following alternative surgical approach for experimental stroke in mice [version 3; peer review: 2 approved] (2020)
Journal Article

Improved reperfusion following alternative surgical approach for experimental stroke in mice (2020)
Journal Article

Background: Following ischemic stroke, recanalisation and restoration of blood flow to the affected area of the brain is critical and directly correlates with patient recovery. In vivo models of ischemic stroke show high variability in outcomes whic... Read More about Improved reperfusion following alternative surgical approach for experimental stroke in mice.

Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia (2018)
Journal Article

Experimental stroke in rodents, via middle cerebral artery occlusion (MCAO), can be associated with a negative impact on wellbeing and mortality. In hypertensive rodents, pre-stroke craniotomy increased survival and decreased body weight loss post-MC... Read More about Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia.

An alternative surgical approach reduces variability following filament induction of experimental stroke in mice (2017)
Journal Article