All Outputs (4)

Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes (2016)
Journal Article

Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions may be more prone to HGT th... Read More about Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes.

Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens (2016)
Journal Article

Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. In contrast, A. fumigatus causes devastating infec... Read More about Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens.

A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress (2016)
Journal Article

Pro- and eukaryotes produce melanin for protection from environmental stress or as virulence determinant. The human pathogenic fungus Aspergillus fumigatus and related Ascomycetes produce dihydroxynaphthalene (DHN) melanin in conidia, which is essent... Read More about A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress.

Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge (2016)
Journal Article

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge... Read More about Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge.