OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.
All Outputs (95)
COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project (2021)
Journal Article
Objectives: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared to the general population. Methods... Read More about COVID-19 infection, admission and death among people with rare autoimmune rheumatic disease in England: results from the RECORDER project.
Population‐based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large‐cell lymphoma using Public Health England data (2021)
Journal Article
Systemic anaplastic large cell lymphoma (sALCL) is a rare T-cell lymphoma associated with poor prognosis after relapse. The immuno-conjugate Brentuximab Vedotin (BV) first became available for relapsed sALCL in England in 2013, following the results... Read More about Population‐based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large‐cell lymphoma using Public Health England data.
Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19 (2021)
Journal Article
Background Radiographic severity may help predict patient deterioration and outcomes from COVID-19 pneumonia. Purpose To assess the reliability and reproducibility of three chest radiograph reporting systems (radiographic assessment of lung edema [RA... Read More about Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19.
The global incidence of bullous pemphigoid: a systematic review and meta-analysis (2021)
Journal Article
Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study... Read More about The global incidence of bullous pemphigoid: a systematic review and meta-analysis.
Improved survival outcomes despite older age at diagnosis: an era‐by‐era analysis of patients with primary central nervous system lymphoma treated at a single referral centre in the United Kingdom (2021)
Journal Article
Observational studies with long-term follow-up of patients with primary central nervous system lymphoma (PCNSL) are scarce. Patient data over a period of four decades were retrospectively analysed from databases at Not-tingham University Hospitals Tr... Read More about Improved survival outcomes despite older age at diagnosis: an era‐by‐era analysis of patients with primary central nervous system lymphoma treated at a single referral centre in the United Kingdom.
External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk (2021)
Journal Article
Introduction: Venous thromboembolism (VTE) is the leading cause of direct maternal mortality in high-income countries. We previously developed a risk prediction score for postpartum venous thromboembolism (VTE) in women without a previous VTE. In thi... Read More about External validation of a model to predict women most at risk of postpartum venous thromboembolism: Maternity clot risk.
A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis (2021)
Journal Article
Objectives: Takayasu arteritis (TAK), is a rare autoimmune rheumatic disease causing large vessel vasculitis. Onset is typically between the ages of 20-30. It is associated with substantial morbidity and mortality, notably due to its effects on the... Read More about A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis.
What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.
?-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study (2021)
Journal Article
Objectives: To examine the association between ?-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain. Methods: Data source: Clinical Practice Research Datalink. Participants aged ?40 years in receipt o... Read More about ?-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: A propensity score-matched cohort study.
Risk of death among people with rare autoimmune diseases compared with the general population in England during the 2020 COVID-19 pandemic (2020)
Journal Article
Objectives: To quantify the risk of death among people with rare autoimmune rheumatic diseases (RAIRD) during the UK 2020 COVID-19 pandemic compared with the general population, and compared with their pre-COVID risk. Methods: We conducted a cohort s... Read More about Risk of death among people with rare autoimmune diseases compared with the general population in England during the 2020 COVID-19 pandemic.
Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology?specific outcome taxonomy (2020)
Journal Article
Background: Standardized outcome reporting is crucial for trial evidence synthesis and translation of findings into clinical decision making. The OMERACT 2.0 Filter and COMET outcome domain taxonomy propose frameworks for consistent reporting of outc... Read More about Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology?specific outcome taxonomy.
Disease activity in inflammatory bowel disease is associated with arterial vascular disease (2020)
Journal Article
Background and Aims: There is evidence that several inflammatory diseases are associated with increased cardiovascular risk. Whether this is true for inflammatory bowel diseases remains controversial. We aimed to assess this risk corrected for the ef... Read More about Disease activity in inflammatory bowel disease is associated with arterial vascular disease.
Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease-modifying anti-rheumatic drugs (2020)
Journal Article
Objectives The effectiveness of inactivated influenza vaccine in people with autoimmune rheumatic disease (AIRDs) is not known. We investigated whether the influenza vaccine is effective in preventing respiratory morbidity, mortality and all-cause m... Read More about Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease-modifying anti-rheumatic drugs.
© Author(s) (or their employer(s)) 2019. Introduction: To investigate if β-adrenoreceptor blocking drug (β-blocker) prescription reduces the risk of knee or hip osteoarthritis, total joint replacement and analgesic prescription. Setting: Primary care... Read More about Do ?-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink.
Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More about Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink.
Don't blame it on the sunshine, don't blame it on the moonlight, don't blame it on good times, blame it on the sociocultural factors (2019)
Journal Article
In this issue of Hepatology, Ventura‐Cots and colleagues present their study arguing that colder weather and fewer sunlight hours increase alcohol consumption and thus cause alcoholic cirrhosis (1). “Causality” is a key concept for this study. A rece... Read More about Don't blame it on the sunshine, don't blame it on the moonlight, don't blame it on good times, blame it on the sociocultural factors.
Temporal relationships between systemic lupus erythematosus and comorbidities (2018)
Journal Article
© The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective: To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality.... Read More about Temporal relationships between systemic lupus erythematosus and comorbidities.
Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article
Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More about Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable.
Visual inspection for diagnosing cutaneous melanoma in adults (2018)
Journal Article
Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious... Read More about Visual inspection for diagnosing cutaneous melanoma in adults.