Population‐based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large‐cell lymphoma using Public Health England data

Halligan, Sarah J.; Grainge, Matthew J.; Martinez-Calle, Nicolas; Fox, Christopher P.; Bishton, Mark J.

Abstract

Systemic anaplastic large cell lymphoma (sALCL) is a rare T-cell lymphoma associated with poor prognosis after relapse. The immuno-conjugate Brentuximab Vedotin (BV) first became available for relapsed sALCL in England in 2013, following the results of a pivotal phase II study. We present a population-based study describing outcomes of relapsed sALCL in England after BV, using Public Health England (PHE) data.

We obtained information on all relapsed/refractory (r/r) sALCL patients ≥18 years treated with BV monotherapy in England between 1st Jan 2014-31st Dec 2019. The final cohort comprised 127 patients with a median age of 60 years (range 19-89). 18 (14.2%) had received stem cell transplant in first remission. Median 2-year overall survival (OS) was 46.6%. The vast majority of deaths (59) occurred within 18 months, with very few events after this. Receipt of BV as second line compared to third or fourth line was associated with significantly improved survival (2-year OS 50.3% vs 29.7%, p = 0.03). There was no difference in OS for different subgroups, including ALK status, age, gender, or receipt of SCT in first response.

We report excellent survival following treatment with BV in a real-world setting, comparable with previous clinical trial data.

• Journal Article Type: Article
• Acceptance Date: Sep 29, 2021
• Online Publication Date: Oct 18, 2021
• Publication Date: 2022-02
• Deposit Date: Oct 19, 2021
• Publicly Available Date: Oct 19, 2022
• Journal: British Journal of Haematology
• Print ISSN: 0007-1048
• Electronic ISSN: 1365-2141
• Peer Reviewed: Peer Reviewed
• Volume: 196
• Issue: 4
• Pages: 932-938
• DOI: https://doi.org/10.1111/bjh.17896
• Public URL: https://nottingham-repository.worktribe.com/output/6503232
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/bjh.17896