All Outputs (12)

Quantification of differences in germination behaviour of pelleted and coated sugar beet seeds using X-ray Computed Tomography (X-ray CT) (2017)
Journal Article

Seed enhancement technologies i.e. priming, pelleting and coating have been extensively9 used throughout the last century to improve crop yield and to reduce losses associated with pest infestation. However, until recently, it has not been possible t... Read More about Quantification of differences in germination behaviour of pelleted and coated sugar beet seeds using X-ray Computed Tomography (X-ray CT).

Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study (2017)
Journal Article

Background: Smoking is associated with a more severe disease course in people with multiple sclerosis (MS). The magnitude of effect of smoking cessation on MS progression is unknown. The aim of this study was to quantify the impact of smoking cessati... Read More about Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study.

Water intake, faecal output and intestinal motility in horses moved from pasture to a stabled management regime with controlled exercise (2014)
Journal Article

Reasons for performing study: A change in management from pasture to stabling is a risk factor for equine colic. Objectives: To investigate the effect of a management change from pasture with no controlled exercise to stabling with light exercise... Read More about Water intake, faecal output and intestinal motility in horses moved from pasture to a stabled management regime with controlled exercise.

Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes (2014)
Journal Article

Background Chondrocytes are regularly exposed to load-induced stimuli and have the capability to sense and respond to applied mechanical stress. However, the mechanisms involved in chondrocyte mechanotransduction are not clearly understood. The pu... Read More about Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes.

Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1? (2013)
Journal Article

Introduction: Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metalloproteinases (MMPs) is partly... Read More about Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?.

Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology (2013)
Journal Article

Mass spectrometry is an analytical technique for the characterization of biological samples and is increasingly used in omics studies because of its targeted, nontargeted, and high throughput abilities. However, due to the large datasets generated, i... Read More about Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology.

Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study (2013)
Journal Article

Tobacco smoking has been linked to an increased risk of multiple sclerosis. However, to date, results from the few studies on the impact of smoking on the progression of disability are conflicting. The aim of this study was to investigate the effects... Read More about Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study.

Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning (2013)
Journal Article

Background: Osteoarthritis (OA) is an inflammatory disease of synovial joints involving the loss and degeneration of articular cartilage. The gold standard for evaluating cartilage loss in OA is the measurement of joint space width on standard radiog... Read More about Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning.

Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes (2012)
Journal Article

Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective c... Read More about Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes.

Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY (2011)
Journal Article

Inflammatory processes play essential roles in the pathogenesis of tendinitis and tendinopathy. These events are accompanied by catabolic processes initiated by pro-inflammatory cytokines such as interleukin-1? (IL-1?) and tumor necrosis factor-? (TN... Read More about Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY.

High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation (2011)
Journal Article

This study employed a targeted high-throughput proteomic approach to identify the major proteins present in the secretome of articular cartilage. Explants from equine metacarpophalangeal joints were incubated alone or with interleukin-1beta (IL-1?, 1... Read More about High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation.

The Virtual International Stroke Trials Archive (2007)
Journal Article

Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for r... Read More about The Virtual International Stroke Trials Archive.