All Outputs (9)

Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years (2023)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., Prestwich, B. L., Noble, R. A., Selby, N. M., …Francis, S. T. (2023). Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years. Journal of Clinical Medicine, 12(23), Article 7282. https://doi.org/10.3390/jcm12237282

Background: Multiparametric renal Magnetic Resonance Imaging (MRI) provides a non-invasive method to assess kidney structure and function, but longitudinal studies are limited. Methods: A total of 22 patients with CKD category G3-4 (estimated glomeru... Read More about Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years.

Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK (2023)
Journal Article
Greenwood, S. A., Young, H. M., Briggs, J., Castle, E. M., Walklin, C., Haggis, L., …Macdonald, J. H. (2024). Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK. Lancet Digital Health, 6(1), E23-E32. https://doi.org/10.1016/S2589-7500%2823%2900204-2

Background: Remote digital health interventions to enhance physical activity provide a potential solution to improve the sedentary behaviour, physical inactivity, and poor health-related quality of life that are typical of chronic conditions, particu... Read More about Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK.

Blood Pressure targets in Chronic Kidney Disease: still no consensus (2023)
Journal Article
Lucas, B., & Taal, M. W. (2023). Blood Pressure targets in Chronic Kidney Disease: still no consensus. Current Opinion in Nephrology and Hypertension, 32(6), 497-501. https://doi.org/10.1097/MNH.0000000000000920

Purpose of review Despite a strong consensus that treatment of hypertension is fundamental to strategies seeking to slow chronic kidney disease (CKD) progression and reduce the associated risk of cardiovascular events (CVE), controversy persists re... Read More about Blood Pressure targets in Chronic Kidney Disease: still no consensus.

Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation (2023)
Journal Article
Nakafero, G., Card, T., Grainge, M. J., Williams, H. C., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. eClinicalMedicine, 64, Article 102213. https://doi.org/10.1016/j.eclinm.2023.102213

Background: Patients established on thiopurines (e.g., azathioprine) are recommended to undergo three-monthly blood tests for the early detection of blood, liver, or kidney toxicity. These side-effects are uncommon during long-term treatment. We deve... Read More about Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation.

Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging (2023)
Journal Article
Gullapudi, V. R. L., Cox, E. F., Buchanan, C. E., Canaud, B., White, K., Taal, M. W., …Francis, S. T. (2024). Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging. Nephrology Dialysis Transplantation, 39(2), 233–241. https://doi.org/10.1093/ndt/gfad150

Background Ischaemic end-organ damage during haemodialysis (HD) is a significant problem that may be ameliorated by intradialytic cooling. A randomised trial was performed to compare standard HD (SHD; dialysate temperature 37°C) and programmed cooli... Read More about Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging.

Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK (2023)
Journal Article
Nakafero, G., Grainge, M. J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK. BMJ, 381, Article e074678. https://doi.org/10.1136/bmj-2022-074678

OBJECTIVE: To develop and validate a prognostic model to inform risk stratified decisions on frequency of monitoring blood tests during long term methotrexate treatment. DESIGN: Retrospective cohort study. SETTING: Electronic health records within th... Read More about Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK.

Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD) (2023)
Journal Article
Taal, M. W., Lucas, B., Roderick, P., Cockwell, P., Wheeler, D. C., Saleem, M. A., …Kalra, P. A. (2023). Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD). Nephrology Dialysis Transplantation, 38(11), 2617–2626. https://doi.org/10.1093/ndt/gfad110

Background Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for cl... Read More about Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD).

Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application (2023)
Journal Article
Francis, S. T., Selby, N. M., & Taal, M. W. (2023). Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application. American Journal of Kidney Diseases, 82(4), 491-504. https://doi.org/10.1053/j.ajkd.2023.02.007

Recent advances in multiparametric magnetic resonance imaging (MRI) allow multiple quantitative measures to assess kidney morphology, tissue microstructure, oxygenation, kidney blood flow, and perfusion to be collected in a single scan session. Anima... Read More about Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application.

Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis (2023)
Journal Article
Taal, M. W., Dukka, H., & Bayston, R. (2023). Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis. Expert Review of Medical Devices, 20(6), 459-466. https://doi.org/10.1080/17434440.2023.2205587

Introduction Peritoneal dialysis (PD) is a widely used dialysis modality, which offers the advantage of being a home therapy but is associated with a risk of potentially serious infections, including exit site infection, catheter tunnel infection, a... Read More about Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis.