The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity

Royer, Pierre Joseph; Emara, Mohamed; Yang, Chaoxing; Al-Ghouleh, Abeer; Tighe, Paddy; Jones, Nick; Sewell, Herb F.; Shakib, Farouk; Martinez-Pomares, Luisa; Ghaemmaghami, Amir M.

doi:10.4049/jimmunol.1000774

All Outputs (2)

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins (2010)
Journal Article

Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation a... Read More about Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.

The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity (2010)
Journal Article

The mannose receptor (MR) is a C-type lectin expressed by dendritic cells (DCs). We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human... Read More about The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity.