Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model
(2022)
Journal Article
Schütt, M., O’Farrell, C., Stamatopoulos, K., Hoad, C. L., Marciani, L., Sulaiman, S., …Alexiadis, A. (2022). Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model. Pharmaceutics, 14(1), Article 184. https://doi.org/10.3390/pharmaceutics14010184
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic... Read More about Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model.