Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men

Stephens, Francis B.; Chee, Carolyn; Wall, Benjamin T.; Murton, Andrew J.; Shannon, Chris E.; van Loon, Luc J.C.; Tsintzas, Kostas

doi:10.2337/db14-0961

All Outputs (4)

Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters (2015)
Journal Article

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) th... Read More about Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters.

Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults (2015)
Journal Article

Background/Objectives: Breakfast omission is positively associated with obesity and increased risk of disease. However, little is known about the acute effects of extended morning fasting upon subsequent energy intake and associated metabolic/reg... Read More about Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults.

Dual effects of fibroblast growth factor 21 on hepatic energy metabolism (2015)
Journal Article

The aim of this study was to investigate the mechanisms by which FGF21 affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters maintained in t... Read More about Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.

Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men (2015)
Journal Article

The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The current study investigated the effect of acutely increasing lipid a... Read More about Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men.