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Dual effects of fibroblast growth factor 21 on hepatic energy metabolism

Samms, Ricardo J.; Murphy, Michelle; Fowler, Maxine J.; Cooper, Scott; Emmerson, Paul; Coskun, Tamer; Adams, Andrew C.; Kharitonenkov, Alexei; Ebling, Francis J.P.; Tsintzas, Kostas

Authors

Ricardo J. Samms

Michelle Murphy

Maxine J. Fowler

Scott Cooper

Paul Emmerson

Tamer Coskun

Andrew C. Adams

Alexei Kharitonenkov

Francis J.P. Ebling



Abstract

The aim of this study was to investigate the mechanisms by which FGF21 affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters maintained in their long day fat state since birth were randomly assigned to one of two treatment groups and were continuously infused with either vehicle (saline; n=6) or recombinant human FGF21 protein (1 mg/kg/day; n=6) for 14 days. FGF21 administration caused a 40% suppression (P

Journal Article Type Article
Publication Date Oct 1, 2015
Journal Journal of Endocrinology
Print ISSN 0022-0795
Electronic ISSN 0022-0795
Publisher BioScientifica
Peer Reviewed Peer Reviewed
Volume 227
Issue 1
APA6 Citation Samms, R. J., Murphy, M., Fowler, M. J., Cooper, S., Emmerson, P., Coskun, T., …Tsintzas, K. (2015). Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. Journal of Endocrinology, 227(1), https://doi.org/10.1530/JOE-15-0334
DOI https://doi.org/10.1530/JOE-15-0334
Keywords FGF21, liver, energy metabolism, Siberian hamster, adiposity
Publisher URL http://joe.endocrinology-journals.org/content/227/1/37.long
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This manuscript has been accepted for publication in Journal of Endocrinology, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at http://dx.doi.org/10.1530/JOE-15-0334 , c2015.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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