All Outputs (2)

Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation (2023)
Journal Article
Kopycka, K., Maddison, B. C., & Gough, K. C. (2023). Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation. Scientific Reports, 13(1), Article 3452. https://doi.org/10.1038/s41598-023-30202-0

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrPC into PrPSc and its accumulation in the central nervous system. Previous st... Read More about Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation.

Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness (2023)
Journal Article
Daly, J. M., Lim, T. S., & Gough, K. C. (2023). Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness. Antibodies, 12(1), Article 7. https://doi.org/10.3390/antib12010007

Driven by necessity, the COVID-19 pandemic caused by SARS-CoV-2 has accelerated the development and implementation of new vaccine platforms and other viral therapeutics. Among these is the therapeutic use of antibodies including single-domain antibod... Read More about Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness.