All Outputs (7)

A quadrivalent vaccine for human papillomavirus (2006)
Journal Article

Cervical cancer is responsible for at least 13,500 deaths a year in the European Union and more than 30 times that worldwide. DNA from a group of human papillomaviruses (HPVs) is found in virtually all cervical carcinoma cells, and these so-called hi... Read More about A quadrivalent vaccine for human papillomavirus.

The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein (2006)
Journal Article

The E2 proteins are transcription/replication factors from papillomaviruses. Human papillomaviruses (HPVs) can be broadly divided in two groups; low-risk HPV subtypes cause benign warts while high-risk HPVs give rise to cervical cancer. Although a ra... Read More about The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

Development of a topical protein therapeutic for human papillomavirus and associated cancers (2006)
Journal Article

E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death (2006)
Journal Article

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain (2006)
Journal Article

Homeodomain proteins regulate multiple developmental pathways by altering gene expression temporally and in a tissue-specific fashion. The Proline Rich Homeodomain protein (PRH/Hex) is a transcription factor and an essential regulator of embryonic de... Read More about Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.

Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction (2006)
Journal Article

The Proline-Rich Homeodomain (PRH) protein is a regulator of transcription and translation and plays a key role in the control of cell proliferation and cell differentiation. PRH contains an N-terminal proline-rich domain that can repress transcripti... Read More about Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy (2006)
Journal Article

Human papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells, expression of the viral E6 an... Read More about Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.